Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEBTUZ3)

DME Name	D-Lactate dehydrogenase (ldhA)
Synonyms	Glycolate dehydrogenase; D-lactate ferricytochrome C oxidoreductase; Fermentative lactate dehydrogenase; D-LDH; FN0511; ldhA
Gene Name	ldhA
UniProt ID	Q8RG11_FUSNN
INTEDE ID	DME1686
Gene ID	992792
EC Number	EC: 1.1.1.28 Oxidoreductase CH-OH donor oxidoreductase NAD/NADP oxidoreductase EC: 1.1.1.28
Lineage	Species: Fusobacterium nucleatum Kingdom: Bacteria Phylum: Fusobacteria Class: Fusobacteriia Order: Fusobacteriales Family: Fusobacteriaceae Genus: Fusobacterium Species: Fusobacterium nucleatum
Tissue Distribution	Primarily distributed in human gut.
Sequence	MQKTKIIFFDIKDYDKEFFKKYGADYNFEMTFLKVRLTEETANLTKGYDVVCGFANDNIN KETIDIMAENGIKLLAMRCAGFNNVSLKDVNERFKVVRVPAYSPHAIAEYTVGLILAVNR KINKAYVRTREGNFSINGLMGIDLYEKTAGIIGTGKIGQILIKILRGFDMKVIAYDLFPN QKVADELGFEYVSLDELYANSDIISLNCPLTKDTKYMINRRSMLKMKDGVILVNTGRGML IDSADLVEALKDKKIGAVALDVYEEEENYFFEDKSTQVIEDDILGRLLSFYNVLITSHQA YFTKEAVGAITVTTLNNIKDFVEGRPLVNEVPQNQ
Function	This enzyme has D-lactate dehydrogenase activity.
KEGG Pathway	Metabolic pathways (fnu01100 ) Microbial metabolism in diverse environments (fnu01120 ) Pyruvate metabolism (fnu00620 )

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Clinical Trial Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
DB-053072	DM1K248	N. A.	N. A.	Phase 1	[1]
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References

1	Diverse allosteric and catalytic functions of tetrameric d-lactate dehydrogenases from three Gram-negative bacteria. AMB Express. 2014 Oct 28;4:76.