Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEBUN2V)

• DME Name: Beta-galactosidase (bgaB)
• Synonyms: Beta-galactosidase/glucuronidase; Beta-galactosidase BgaBeta; Beta-Gal II; Beta-gal; lacA
• Gene Name: lacA
• UniProt ID: BGAL2_LACAI
• INTEDE ID: DME1715
• EC Number:
  EC: 3.2.1.23
  Hydrolases
  Glycosylase
  O/S-glycosyl compound glycosidase
  EC: 3.2.1.23
• Lineage:
  Species: Lactobacillus acidophilus
  Kingdom: Bacteria
  Phylum: Firmicutes
  Class: Bacilli
  Order: Lactobacillales
  Family: Lactobacillaceae
  Genus: Lactobacillus
  Species: Lactobacillus acidophilus
• Tissue Distribution: Primarily distributed in human gut.
• Sequence:
  MTQLSRFLYGGDYNPDQWPEETWSKDIHVFKKADINSATINIFSWALLEPREGKYNFSKL
  DKVVQQLSDANFDIVMGTATAAMPAWMFKKYPDIARVDYQDRRHVFGQRHNFCPNSSNYQ
  RLAGELEKQLVERYKDNKHIVFWHINNEYGGNCYCENCQNAFKKWLKNKYKTVEGLNKAW
  NMNVWSHTIYDWDEIVVPNELGDVWGIKGSETIVAGLSIDYLRFQSESMQNLFKMEKKII
  KKFDPETPVTTNFHGLPNKMVDYQKWAKGQDIISYDSYPTYDAPAYKAAFLYDLMRSLKH
  QPFMLMESAPSQVNWQPYSPLKRPGQMEATEFQAVAHGADTVQFFRLKQAVGGSEKFHSA
  VIAHSQRTVTRVFKELADLGKKLKNAGPTILGSKTKARFAIVFDWSNFWSYEYVDGITQD
  LNYVDSILDYYRQFYERNIPTDIIGVDDDFSNYDLVVAPVLYMVKHGLDKKINDYVENGG
  NFVTTYMSGMVNSSDNVYLGGYPGPLKEVTGIWVEESDAVVPGQKIKVLMNGKDYDTGLI
  CNLIHPNDAKILATYASEFYAGTPAVTENQYGKGRAWYIGTRLEHQGLTQLFNHIIFETG
  VESLVCDSHKLEITKRVTEDGKELYFVLNMSNEERTLPSKFTGYEDILTGEKAHKDMKGW
  DVQVLRN
• Function: This enzyme hydrolyzes lactose, oNP-galactoside (oNPG), pNP-galactosidase (pNPG), pNP-mannoside, pNP-glucoside, pNP-fucoside, pNP-N-acetylglucosamide.

Molecular Interaction Atlas (MIA) of This DME

1 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Raffinose	DMVHDOS	N. A.	N. A.	Investigative	[1]

References

• [1] Differential proteome and cellular adhesion analyses of the probiotic bacterium Lactobacillus acidophilus NCFM grown on raffinose - an emerging prebiotic. Proteomics. 2016 May;16(9):1361-75.