Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEBW1FU)

DME Name	Fructokinase (scrK)
Synonyms	D-fructose(D-mannose)kinase; D-fructose kinase; Fructo kinase; D-fructokinase; cscK, OsFK; scrK; CL6EHI_054510
Gene Name	scrK
UniProt ID	SCRK_FUSMR
INTEDE ID	DME1136
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
EC Number	EC: 2.7.1.4 Transferase Kinase Phosphotransferase EC: 2.7.1.4
Lineage	Species: Fusobacterium mortiferum Kingdom: Bacteria Phylum: Fusobacteria Class: Fusobacteriia Order: Fusobacteriales Family: Fusobacteriaceae Genus: Fusobacterium Species: Fusobacterium mortiferum Subspecies: Fusobacterium mortiferum ATCC 25557 Subspecies: Fusobacterium mortiferum ATCC 9817
Tissue Distribution	Primarily distributed in human gut.
Sequence	MIIGAVEAGGTKFVDGVGNEKGEIFER
Function	This enzyme has fructokinase activity, involved metal ion binding, and cellular carbohydrate catabolic process.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Clinical Trial Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Maltose	DMH0ROP	N. A.	N. A.	Phase 1/2	[1], [2]
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1 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sucrose	DMVWUCF	Discovery agent	N.A.	Investigative	[1]
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References

1	Sugar metabolism by fusobacteria: regulation of transport, phosphorylation, and polymer formation by Fusobacterium mortiferum ATCC 25557. Infect Immun. 1991 Dec;59(12):4547-54.
2	Clinical Fusobacterium mortiferum isolates cluster with undifferentiated Clostridium rectum species based on 16S rRNA gene phylogenetic analysis. Ann Clin Lab Sci. 2016 May;46(3):279-81.