Details of Drug-Metabolizing Enzyme (DME)
General Information of Drug-Metabolizing Enzyme (DME) (ID: DEBY951)
| DME Name | Cytochrome P450 21A2 (cyp21) | ||||
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| Synonyms | Cytochrome P450 family 21 subfamily A member 2; Cytochrome cyp21A2; P450 21A2; cyp21A2 | ||||
| Gene Name | cyp158a2_1 | ||||
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| EC Number | EC: 1.14.14.16 | ||||
| Lineage | Species: Bacillus megaterium | ||||
| Tissue Distribution | Primarily distributed in human gut. | ||||
| Sequence |
MTEKTMPGPLPPVRHWPALDLKGVDFDPVLSELMREGPVTRIQLPNGEGWAWLVTRHDDV
RMVANDPRFGREAVVDQPVTRLAPHFIPARGAVGFLDPPDHTRLRRSVAAAFTARGVERV RDKARRTLDVMVDELLRIGPPADLTEAVLSPFPIAVICELMGVPADDRRGMHTWTQLILS SAHGAEVSEKAKDEMGAYFRKLIGARNDSRDEDVTSLLGAAVGRDEIDLEEAVGLAVLLQ IGGEAVTNNSGQMFYLLLTRPALADRLRSDPRIRPQAIDELLRYIPHRNMVGLSRIARED VEIRGVQIRAGDPIYVSYLAANRDPEVFPDPEHIDFGRSPNPHVAFGFGPHYCPGGMLAR LESELLVEALVDRLPGLRLAVPPSQVPFRKGALIRGPEALPVTW |
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| Function |
This enzyme is a P-450 heme-thiolate protein and it responsible for the conversion of progesterone and 17alpha-hydroxyprogesterone to their respective 21-hydroxylated derivatives, 11-deoxycorticosterone and 11-deoxycortisol. Involved in the biosynthesis of the hormones aldosterone and cortisol. The electron donor is NADPH---hemoprotein reductase.
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Molecular Interaction Atlas (MIA) of This DME
| Molecular Interaction Atlas (MIA) | ||||||||||||||||||||||||||||
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1 Approved Drug(s) Metabolized by This DME
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References