Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DECT13Q)

DME Name	Cytochrome P450 107L2 (cyp107)
Synonyms	Cytochrome P450 family 107 subfamily L member 2; Cytochrome P450 monooxygenase 107L2; Narbomycin C-12 hydroxylase 107L2; Pikromycin synthase CYP107L2
Gene Name	pikC
UniProt ID	PIKC_STRVZ
INTEDE ID	DME2063
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
EC Number	EC: 1.14.15.11 Oxidoreductase Oxygen paired donor oxidoreductase Iron-sulfur protein donor oxidoreductase EC: 1.14.15.11
Lineage	Species: Streptomyces avermitilis Kingdom: Bacteria Phylum: Actinobacteria Class: Actinobacteria Order: Streptomycetales Family: Streptomycetaceae Genus: Streptomyces Species: Streptomyces avermitilis
Tissue Distribution	Primarily distributed in human gut.
Sequence	MRRTQQGTTASPPVLDLGALGQDFAADPYPTYARLRAEGPAHRVRTPEGDEVWLVVGYDR ARAVLADPRFSKDWRNSTTPLTEAEAALNHNMLESDPPRHTRLRKLVAREFTMRRVELLR PRVQEIVDGLVDAMLAAPDGRADLMESLAWPLPITVISELLGVPEPDRAAFRVWTDAFVF PDDPAQAQTAMAEMSGYLSRLIDSKRGQDGEDLLSALVRTSDEDGSRLTSEELLGMAHIL LVAGHETTVNLIANGMYALLSHPDQLAALRADMTLLDGAVEEMLRYEGPVESATYRFPVE PVDLDGTVIPAGDTVLVVLADAHRTPERFPDPHRFDIRRDTAGHLAFGHGIHFCIGAPLA RLEARIAVRALLERCPDLALDVSPGELVWYPNPMIRGLKALPIRWRRGREAGRRTG
Function	This enzyme is a P-450 heme-thiolate protein, and it is involved in the biosynthesis of a number of bacterial macrolide antibiotics containing a desosamine glycoside unit.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lauric Acid	DM9C8KQ	Discovery agent	N.A.	Investigative	[1], [2]
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References

1	The metagenome of Caracolus marginella gut microbiome using culture independent approaches and shotgun sequencing. Data Brief. 2017 Nov 22;16:501-505.
2	Structural insights into the binding of lauric acid to CYP107L2 from Streptomyces avermitilis. Biochem Biophys Res Commun. 2017 Jan 22;482(4):902-908.