Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DECWNTP)

DME Name Beta-fructofuranosidase (BFRU)
Synonyms Sucrose-6-phosphate hydrolase; Invertase; Glycoside hydrolase family 32 protein; DPC6316_1322; DWV93_02555
Gene Name cscA
UniProt ID
E1CPU3_BIFLN
INTEDE ID
DME1162
EC Number EC: 3.2.1.26
Hydrolases
Glycosylase
O/S-glycosyl compound glycosidase
EC: 3.2.1.26
Lineage Species: Bifidobacterium longum
Kingdom: Bacteria
Phylum: Actinobacteria
Class: Actinobacteria
Order: Bifidobacteriales
Family: Bifidobacteriaceae
Genus: Bifidobacterium
Species: Bifidobacterium longum
Tissue Distribution Primarily distributed in human oral cavity.
Sequence
MTDFTPETPVLTPIRDHAAELAKAEAGVAEMAAKRNNRWYPKYHIASNGGWINDPNGLCF
YKGLWHVFYQLHPYGTQWGPMHWGHVSSTDMLSWKREPIMFAPSLEQEKDGVFSGSAVID
DNGDLRFYYTGHRWANGHDNTGGDWQVQMTALPDNDELTSATKQGMIIDCPTDKVDHHYR
DPKVWKTGDTWYMTFGVSSADKRGQMWLFSSKDMVRWEYERVLFQHPDPDVFMLECPDFF
PIKDKDGNEKWVIGFSAMGSKPSGFMNRNVSNAGYMIGTWEPGGEFKPETEFRLWDCGHN
YYAPQSFNVEGRQIVYGWMSPFVQPIPMEDDGWCGQLTLPREITLGDDGDVVTAPVAEME
GLREDTLDHGSITLDMDGEQIIADDAEAVEIEMTIDLAASTAERAGLKIHATEDGAYTYV
AYDDQIGRVVVDRQAMANGDRGYRAAPLTDAELASGKLDLRVFVDRGSVEVYVNGGHQVL
SSYSYASEGPRAIKLVAESGSLKVDSLKLHHMKSIGLE
Function This enzyme takes part in glucuronoside catabolic process. Substrates include sucrose.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DME
1 Preclinical Drug(s) Metabolized by This DME
Drug Name Drug ID Indication ICD 11 Highest Status REF
Kestose DML93TN N. A. N. A. Preclinical [1]
1 Investigative Drug(s) Metabolized by This DME
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sucrose DMVWUCF Discovery agent N.A. Investigative [1]

References

1 Characterization of fructooligosaccharide-degrading enzymes in human commensal Bifidobacterium longum and Anaerostipes caccae. Biochem Biophys Res Commun. 2019 Oct 15;518(2):294-298.