Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DECY6JG)

DME Name D-Lactate dehydrogenase (ldhA)
Synonyms Glycolate dehydrogenase; D-lactate ferricytochrome C oxidoreductase; Fermentative lactate dehydrogenase; D-LDH; JW1375; b1380; hslI; htpH; ldhA
Gene Name ldhA
UniProt ID
LDHD_ECOLI
INTEDE ID
DME1690
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Gene ID
946315
EC Number EC: 1.1.1.28
Oxidoreductase
CH-OH donor oxidoreductase
NAD/NADP oxidoreductase
EC: 1.1.1.28
Lineage Species: Escherichia coli
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Escherichia
Species: Escherichia coli
Tissue Distribution Primarily distributed in human gut.
Sequence
MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV
LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI
HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA
ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS
QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT
AEALTSISQTTLQNLSNLEKGETCPNELV
Function This enzyme has D-lactate dehydrogenase activity.
KEGG Pathway
Metabolic pathways (ecj01100 )
Microbial metabolism in diverse environments (ecj01120 )
Pyruvate metabolism (ecj00620 )

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DME
1 Clinical Trial Drug(s) Metabolized by This DME
Drug Name Drug ID Indication ICD 11 Highest Status REF
DB-053072 DM1K248 N. A. N. A. Phase 1 [1]

References

1 Diverse allosteric and catalytic functions of tetrameric d-lactate dehydrogenases from three Gram-negative bacteria. AMB Express. 2014 Oct 28;4:76.