Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEDI8VX)

DME Name	Propanediol dehydrogenase (dhaT)
Synonyms	Dehydrogenase propanediol; 1,3-propanediol dehydrogenase; 13-propanediol dehydrogenase; AZI11_12055; CCS05_11470; CNR29_12615; LbDm2_1760; NCTC13386_00196; UCCLBBS449_2334; dhaT
Gene Name	dhaT
UniProt ID	A0A0C1Q6R1_LACBR
INTEDE ID	DME1058
Gene ID	4413383
EC Number	EC: 1.1.1.202 Oxidoreductase CH-OH donor oxidoreductase NAD/NADP oxidoreductase EC: 1.1.1.202
Lineage	Species: Lactobacillus brevis Kingdom: Bacteria Phylum: Firmicutes Class: Bacilli Order: Lactobacillales Family: Lactobacillaceae Genus: Lactobacillus Species: Lactobacillus brevis Subspecies: Lactobacillus brevis 6239 Subspecies: Lactobacillus brevis B22
Tissue Distribution	Primarily distributed in human gut.
Sequence	MAERSYDFLMPSVNFFGPGVISKIGDRAKMLGMKKPVIVTDKFLEGLKDGAVEQTLDSLK AAGVDYVVYNNVEPNPKIRNIKEVKKLYEESGADSIITVGGGSAHDTGKGAGIILTNGDD ITKLAGIETLDKALPPLIAVNTTAGTGSELTRHAVITNEETHLKFVVVSWRNIPLVSFND PTLMLDVPKGLTAATGMDAFVQAVEPYVSVDHNPITDSQCVEAIKLIETSLREAVANGHN LDARTKMVEAEMLAGMAFNNANLGYVHAMAHQLGGQYDAPHGVCCALLLPYVEEYNIIAC PDRFAQLAEIMGENTEGLSTRDAAELAIKAMKQLSEDVGIPHSIKEIGAKPEDFELMAEN ALKDGNAFSNPRKGTKEDIIKIFQAAYDAE
Function	This enzyme uses NAD+ to oxidize 1,3-propanediol, glycerol, ethanol and 1,2-propanediol. This enzyme required Mn2+ and are probably octamers with a molecular mass of 350 kDa.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glycerol phenylbutyrate	DMDGRQO	Hepatic encephalopathy	DB99.5	Approved	[1]
------------------------------------------------------------------------------------

References

1	Expression and characterization of a novel 1,3-propanediol dehydrogenase from Lactobacillus brevis. Appl Biochem Biotechnol. 2016 Jul;179(6):959-72.