Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEE8RS0)

DME Name Beta-glucosidase (bglA)
Synonyms Periplasmic beta-glucosidase; Glucan endo-1 3-beta-D-glucosidase; Beta-D-glucosidase; Thermostable beta-glucosidase B; ERS852400_02722
Gene Name bglB
UniProt ID
A0A174GPV4_9FIRM
INTEDE ID
DME1887
EC Number EC: 3.2.1.21
Hydrolases
Glycosylase
O/S-glycosyl compound glycosidase
EC: 3.2.1.21
Lineage Species: Coprococcus eutactus
Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Lachnospiraceae
Genus: Coprococcus
Species: Coprococcus eutactus
Tissue Distribution Primarily distributed in human gut.
Sequence
MEDRVLDWAVYEKTAREMAAEGLVLLKNDNKALPLKQGETVSVFGRMQNHYYKSGTGSGG
MVNVARVVGILDALNECKDVNVNQKLAETYAAWDKEHPVELGLGWGQEPWSQAEMPVTEE
LVQEAAGESDSAIVIIARTAGEDKDNTLEKGAFMLTDIETDMLRLVRENFQKMVVLLNVG
GLIDMSFLDTISPDACMYVWQGGMVGGYGVADVLVGDVSPSGKLTDTIAYDIKDYPAYDN
FGGEERNFYAEDIYVGYRYFETFAKDKVRYPFGYGLSYTDFKIGVKHASLDFEKGVANIC
VKVTNTGKRLGKEVVQVYGEMPQGRLGKPSRVLIDFAKTKELVPGLSDELKFEIPLDRMA
SFDDSGVTGHRNCYVLEAGDYTIHVGNSIRNTTECLFFELAEIVELQKLQEALAPYEKFD
RMKPFCDENGRMLIEYEETPLVTVDMYDRREQELPEEIPVTGDKGIMLLDVREGRATMDE
FIAQFDDEDLACFVRGEGMGSSLVTAGTASAFAGVSPNLIAHKIPSVCCDDGPSGMRLDS
GMKAFSLPNGTLCGCSFNKELNTRLYALLGLEMTANKVEVLLGPGMNIHRHPLNGRNFEY
FSEDPYLTGSIATAQLEGLKSSGVSGTIKHFCGNNQEYHRHTTDSVISQRALREIYLKGF
EIAVKSGYADSVMTTYGLVNGLYTAGSYDLNTTILRNEWGFTGVVMTDWWASINRRGMEP
DANDFATMIQAQNDMYMCCPDGSKNMGGDNVIEALQDGRILRAELQRIAKNVCNFAMNTN
AFKRLVGEPVEVEIINRPKQADDFSIDDVEYINVDRDILIDLTEKASTADTNYVIALDVE
HPGEYEVSLRGSSTLEKLAQLPCTLFFNGFPVSNFTFNGTDGKDVVIRKEVKFYGRFNVL
RLYVKSNGLDLKDIKFSFEKEF
Function This enzyme has wide specificity for beta-D-glucosides such as beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, beta-D-fucosides.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DME
1 Investigative Drug(s) Metabolized by This DME
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ginsenoside Rb1 DMF70AB N. A. N. A. Investigative [1]

References

1 Developing a metagenomic view of xenobiotic metabolism. Pharmacol Res. 2013 Mar;69(1):21-31.