Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEEZYQV)

DME Name	Amylosucrase (AMS)
Synonyms	Sucrose-1,4-alpha-glucan glucosyltransferase; Sucrose-glucan glucosyltransferase; Sucrose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase; Dgeo_0572
Gene Name	AMS
UniProt ID	Q1J0W0_DEIGD
INTEDE ID	DME1166
EC Number	EC: 2.4.1.4 Transferase Glycosyltransferases Hexosyltransferase EC: 2.4.1.4
Lineage	Species: Deinococcus geothermalis Kingdom: Bacteria Phylum: Deinococcusthermus Class: Deinococci Order: Deinococcales Family: Deinococcaceae Genus: Deinococcus Species: Deinococcus geothermalis Subspecies: Deinococcus geothermalis HLHK9
Tissue Distribution	Primarily distributed in human gut.
Sequence	MLKDVLTSELAAQVRDAFDDDRDAETFLLRLERYGEDLWESLRAVYGDQVRALPGRLLEV MLHAYHARPAELRRLDEARLLRPDWLQRPEMVGYVAYTDRFAGTLKGVEERLDYLEGLGV KYLHLMPLLRPREGENDGGYAVQDYRAVRPDLGTMDDLSALARALRGRGISLVLDLVLNH VAREHAWAQKARAGDPKYRAYFHLFPDRRGPDAFEATLPEIFPDFAPGNFSWDEEIGEGE GGWVWTTFNSYQWDLNWANPDVFLEFVDIILYLANRGVEVFRLDAIAFIWKRLGTDCQNQ PEVHHLTRALRAAARIVAPAVAFKAEAIVAPADLIHYLGTRAHHGKVSDMAYHNSLMVQL WSSLASRNTRLFEEALRAFPPKPTSTTWGLYVRCHDDIGWAISDEDAARAGLNGAAHRHF LSDFYSGQFPGSFARGLVFQYNPVNGDRRISGSAASLAGLEAALETGDPGRIEDAVRRLL LLHTVILGFGGVPLLYMGDELALLNDYAFEDVPEHAPDNRWVHRPQMDWALAERVRQEPS SPAGRVNTGLRHLLRVRRDTPQLHASIESQVLPSPDSRALLLRRDHPLGGMVQVYNFSEE TVMLPSHVLRDVLGDHVQDRLSGSAFRLDRPTVRLEGYRALWLTAGEAPA
Function	This enzyme catalyzes the glucosylation of flavonoids with sucrose as a sugar donor.
KEGG Pathway	Metabolic pathways (dge01100 ) Starch and sucrose metabolism (dge00500 )

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

2 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
7,8,4'-trihydroxyisoflavone	DM80GFL	Discovery agent	N.A.	Investigative	[1], [2]
Caffeic acid phenethyl ester	DMRJKIV	Discovery agent	N.A.	Investigative	[2], [3]
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References

1	Potential industrial production of a well-soluble, alkaline-stable, and anti-inflammatory isoflavone glucoside from 8-hydroxydaidzein glucosylated by recombinant amylosucrase of Deinococcus geothermalis. Molecules. 2019 Jun 15;24(12). pii: E2236.
2	The complete genome and proteome of Laribacter hongkongensis reveal potential mechanisms for adaptations to different temperatures and habitats. PLoS Genet. 2009 Mar;5(3):e1000416.
3	Glycosylation enhances the physicochemical properties of caffeic acid phenethyl ester. J Microbiol Biotechnol. 2017 Nov 28;27(11):1916-1924.