Details of Drug-Metabolizing Enzyme (DME)
General Information of Drug-Metabolizing Enzyme (DME) (ID: DEF4X7T)
| DME Name | Beta-porphyranase A (GH86A) | ||||
|---|---|---|---|---|---|
| Synonyms | Endo-beta-porphyranase A; Glycosyl hydrolase 86 family protein A; BpGH86A; GH86A; BACPLE_01693 | ||||
| Gene Name | GH86A | ||||
| UniProt ID | |||||
| INTEDE ID | |||||
| Gene ID | |||||
| EC Number | EC: 3.2.1.178 | ||||
| Lineage | Species: Bacteroides plebeius | ||||
| Tissue Distribution | Primarily distributed in human gut. | ||||
| Sequence |
MSYKYIFLLSAFTLGVPPGIYCQGRNEVVVDYNTRRFLSGVSELDRSKYFNIHSTSDDDK
DVGKFLADYQVGLGRKFWGPYSYAYNKTHEVGKYPQMKPYSGNISVKRYIATEHPYVQHI QGGIDVQAAGAWSAEYYSNSELVPEFFEPLNEPFVHANDAGFTVQGQAMRELMVDFYASI GKHIHNNPRLNGKMKVIGYAAAYPAWEDGNFNYWNTRMKMFIDRAGAYMDGFSVHLYDGI NVTGTDTKRSGSNSEAVLDMVEAYSYIKFGHVKPLAISEFGGIDNSKPDDSYDDISSVRS VSSFNHFLFNLMERQDNLFISIPFVSDKAEWHITAANNYTSYSAALFIPDNPQNLKNTTW RLNDKKYFFELWKNVKGERVDITSSNPDIQVQAFKDGGRLYIALDNLDDNPQTVYLNNKN SWKDVSNVTKRSLYVNYNAGIEYTEQNVPSMPESISIVPNQTIVLVADVSSSAFTNSIIR NKYYSSEYLKPISAGSSLSFPFTGIESGSGRASLRMSIGRPVSASKKPVVKINGTAVSVP DNWKGYGQSNRNIFFGMIEVPFDIQLLKNGDNNVDITFSDGGGHVSSMILQVEKYTVSTL QNGTFSEGLSAWQPLGNYGTVCVQTDNAGNNVACISGHAGLMQRVDMESGRTYRFSADVK TEGACKLKVMLQDMSTGTVYTEEFSSPGNYKAVSFDFNSTVKKVVCAIVCERQNDAAWID NIVLLPQN |
||||
| Function |
This enzyme cleaves the sulfated polysaccharide porphyran at the (1->4) linkages between beta-D-galactopyranose and alpha-L-galactopyranose-6-sulfate, forming mostly the disaccharide alpha-L-galactopyranose-6-sulfate-(1->3)-beta-D-galactose. Some longer oligosaccharides of even number of residues are also observed. And the enzyme is inactive on the non-sulfated agarose portion of the porphyran backbone.
|
||||
Molecular Interaction Atlas (MIA) of This DME
| Molecular Interaction Atlas (MIA) | ||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
1 Investigative Drug(s) Metabolized by This DME
|
||||||||||||||||||||||||||||