Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEF5JD3)

DME Name	Arylamine N-acetyltransferase (NAT)
Synonyms	N-hydroxyarylamine O-acetyltransferase; nhoA; nhoA_1; SAMEA1713070_01652
Gene Name	nhoA_1
UniProt ID	A0A1C3Q7F5_KLEPN
INTEDE ID	DME1106
EC Number	EC: 2.3.1.5 Transferase Acyltransferase Acyltransferase EC: 2.3.1.5
Lineage	Species: Klebsiella pneumoniae Kingdom: Bacteria Phylum: Proteobacteria Class: Gammaproteobacteria Order: Enterobacterales Family: Enterobacteriaceae Genus: Klebsiella Species: Klebsiella pneumoniae Subspecies: Klebsiella pneumoniae subsp. Ozaenae Subspecies: Klebsiella pneumoniae subsp. Rhinoscleromatis
Tissue Distribution	Primarily distributed in human gut.
Sequence	MSPFLRAYFSRLGWTGEPDVSIDTLRQLHLQHNSAIPFENLDVLLPREIHLDDLALEAKL IAGRRGGYCFEQNGLLERALREIGFNVRSLLGRVVLANPPQMPPRTHRLLLVEVAGERWI ADVGFGGQTLTAPIKLLADIPQQTPHGSYRLVHEGDEWTLQFNHHEHWQSMYHFDLGRQY ASDYVMGNFWSAHWPQSHFRHHLLMCRHLPDGGKMTLTNFHFTHWENNHVVEKVDFADVS ALYEGLQTRFGLGVDDPKHGFSEAALAAVMAAFDTHPEAGK
Function	This enzyme is wide specificity for aromatic amines, including serotonin and it also catalyses acetyl-transfer between arylamines without CoA.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Asacolitin	DM3WVPJ	N. A.	N. A.	Investigative	[1]
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References

1	Identification and functional characterization of arylamine N-acetyltransferases in eubacteria: evidence for highly selective acetylation of 5-aminosalicylic acid. J Bacteriol. 2001 Jun;183(11):3417-27.