Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEFVHQU)

DME Name	Glycerol-3-phosphate dehydrogenase (gpsA)
Synonyms	Dihydroxyacetone-phosphate reductase; GPD-C; GPDH-C; gpsA
Gene Name	gpsA
UniProt ID	A0A411LCN0_ERYRH
INTEDE ID	DME1029
EC Number	EC: 1.1.1.94 Oxidoreductase CH-OH donor oxidoreductase NAD/NADP oxidoreductase EC: 1.1.1.94
Lineage	Species: Erysipelothrix rhusiopathiae Kingdom: Bacteria Phylum: Firmicutes Class: Erysipelotrichia Order: Erysipelotrichales Family: Erysipelotrichaceae Genus: Erysipelothrix Species: Erysipelothrix rhusiopathiae
Tissue Distribution	Primarily distributed in human gut.
Sequence	GHEVMMWGRKLDQVVDVHLYHLNEEFFPGVKLNERLDATQNFEDILDSQIILLAVPTGAV EEVCIELNAHLSNPVIIINVAKGLHPTTHELLDHVIKRVIDSNKLKGVVSLIGPSHAEEV VLRKITTINAVSDNPALAEEVQVLFSNDYFRVYTNDDVIGSQYGVAIKNVIALASGIAAG LDAGDNARAALITRGLTEMQRFGVHMGGQPETYLGLCGVGDLVVTATSVHSRNFQAGMEI GQKNSAVGFLDHNTKTVEGVFAAKVVYEIAVEEGIDMPITEQIYKIIYEEKR
Function	This enzyme shows specificity for the B side of NADPH.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[1], [2]
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References

1	Porcine beta-defensin 2 displays broad antimicrobial activity against pathogenic intestinal bacteria. Mol Immunol. 2008 Jan;45(2):386-94.
2	Dehydrogenase activity of chlornitromycin-resistant variants of Erysipelothrix rhusiopathiae. Izv Mikrobiol Inst (Sofiia). 1969;20:257-62.