Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEG8NJD)

• DME Name: Alcohol dehydrogenase (ADH)
• Synonyms: Alcohol dehydrogenase AdhP; Zinc-dependent alcohol dehydrogenase; Zn-dependent alcohol dehydrogenase; CYK00_08895
• Gene Name: ADH
• UniProt ID: A0A2I1XAT4_NEISI
• INTEDE ID: DME1906
• EC Number:
  EC: 1.1.1.1
  Oxidoreductase
  CH-OH donor oxidoreductase
  NAD/NADP oxidoreductase
  EC: 1.1.1.1
• Lineage:
  Species: Neisseria sicca
  Kingdom: Bacteria
  Phylum: Proteobacteria
  Class: Betaproteobacteria
  Order: Neisseriales
  Family: Neisseriaceae
  Genus: Neisseria
  Species: Neisseria sicca
• Tissue Distribution: Primarily distributed in human oral cavity.
• Sequence:
  MKAMVYHGANDIRFEEKPRPQIIDPTDAVVKIVKTTICGTDLGIWKGKNPEVADGRILGH
  EGIGIVEEVGEAVKNIKVGDKVIISCVSKCCTCDNCKIQLYSHCRNGGWILGYIIDGTQA
  EYVRTPYADNSLVPLPDNVNEEVALLLSDALPTAHEIGVQYGDVKPGDTVFIAGAGPVGM
  SALLTAQLYSPAAIIVCDMDENRLKLAKELGATHTISPASGDVSKQVFAIVGEDGVDCAI
  EAVGIPATWNMCQDIVKPGGHIAVVGVHGQSVDFKLEKLWIKNLAITTGLVNANTTEMLM
  KAISSSSVDYTKMLTHHFKFSELEKAYDVFKHAAENQAMKVVLEAD
• Function: This enzyme acts on primary or secondary alcohols or hemi-acetals with very broad specificity and the enzyme oxidizes methanol much more poorly than ethanol.

Molecular Interaction Atlas (MIA) of This DME

1 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[1]

References

• [1] Functional profiles of coronal and dentin caries in children. J Oral Microbiol. 2018 Jul 16;10(1):1495976.