Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEH3ABM)

DME Name	Nitroreductase (NTR)
Synonyms	FMN reductase (NAD(P)H); FMN reductase NADPH; nfrA2; DCW51_03155
Gene Name	DCW51_03155
UniProt ID	A0A351QTB1_CLOSP
INTEDE ID	DME1246
EC Number	EC: 1.5.1.39 Oxidoreductase CH-NH donor oxidoreductase NAD/NADP acceptor oxidoreductase EC: 1.5.1.39
Lineage	Species: Clostridium hiranonis Kingdom: Bacteria Phylum: Firmicutes Class: Clostridia Order: Clostridiales Family: Peptostreptococcaceae Genus: Clostridium Species: Clostridium hiranonis
Tissue Distribution	Primarily distributed in human gut.
Sequence	MNKEYLNDTIKLLCERASCRSFLDKKIPDELLNEIISCGLHAATGGNLQPYSIIKITDDK TKERLVNECDMQSLVKNAPVNLLFCIDWRRIQRWCEASDAPFVATKSYRHFWIALQDTII CAQNICTAADSIGLGSVYIGTVESCFMELKSIFNIPEGVFPVVLLSIGYPNQPLIPAPKL GIEAIVHEESYKDLTIDTLVKLQNEKYNSKKFPLSPTNTASMKEVTLDIGGEDYSNKIIT SIEQQGYINMAQRYFGLHYKANWSCIGNKNFIEALKAYGFTWIMGEDFPTGDK
Function	This enzyme uses NADH as source of reducing equivalents to reduce of a variety of nitroaromatic compounds.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitrofurantoin	DM7PQIK	Urinary tract infection	GC08	Approved	[1]
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1 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
P-nitrobenzoic acid	DMVJUOZ	N. A.	N. A.	Investigative	[1]
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References

1	Isolation of nitrofurantoin-resistant mutants of nitroreductase-producing Clostridium sp. strains from the human intestinal tract. Antimicrob Agents Chemother. 1998 May;42(5):1121-6.