Details of Drug-Metabolizing Enzyme (DME)
General Information of Drug-Metabolizing Enzyme (DME) (ID: DEHD2Q8)
| DME Name | Glycosyltransferase (Gtf) | ||||
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| Synonyms | Archaeal glycosylation protein; Glycosyltransferase/acyltransferase penicillin-binding protein; C3V41_10425; GTF | ||||
| Gene Name | C3V41_10425 | ||||
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| EC Number | EC: 2.4.1.155 | ||||
| Lineage | Species: Actinomyces howellii | ||||
| Tissue Distribution | Primarily distributed in human oral cavity. | ||||
| Sequence |
MPEPQEVPALTPSASVIVPSYRGEARLPVLLGGLAQQDTTDFEVVVVIDGEVDASAAVLA
GLGESTGLDLDVIVFPRNRGRVAALNAGHAAARGEVLIRCDDDLLPAPDFVSGHVARHAH HGPRGVVALANDVMPDSPYARAYGVRSMDHLIASAYAGDIEPWRLWSANCSLTRGTWEQV GEYSQEYAHYGMEDTDYGYRLHQAGIPLVIAPELQVAHLGAPTSTHDRVMRAFHSGASRR TFEARHGSALSLPSAGTGPWGRLVDGLSRAGDEPRYERATRAVDRLLPYVPRYVAEKLVA LCVESASLAGYRHAQDVTASF |
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| Function |
This enzyme requires Mg2+ and it catalyses the addition of N-acetylglucosamine in beta 1-6 linkage to the alpha-linked mannose of biantennary N-linked oligosaccharides, and thus enables the synthesis of tri- and tetra-antennary complexes.
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Molecular Interaction Atlas (MIA) of This DME
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2 Preclinical Drug(s) Metabolized by This DME
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