Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEHUP0C)

DME Name	D-Lactate dehydrogenase (ldhA)
Synonyms	Glycolate dehydrogenase; D-lactate ferricytochrome C oxidoreductase; Fermentative lactate dehydrogenase; D-LDH; Ldb0101; ldhA
Gene Name	ldhA
UniProt ID	LDHD_LACDA
INTEDE ID	DME1687
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Gene ID	4085369
EC Number	EC: 1.1.1.28 Oxidoreductase CH-OH donor oxidoreductase NAD/NADP oxidoreductase EC: 1.1.1.28
Lineage	Species: Lactobacillus delbrueckii Kingdom: Bacteria Phylum: Firmicutes Class: Bacilli Order: Lactobacillales Family: Lactobacillaceae Genus: Lactobacillus Species: Lactobacillus delbrueckii Subspecies: Lactobacillus delbrueckii subsp. bulgaricus
Tissue Distribution	Primarily distributed in human gut.
Sequence	MTKIFAYAIREDEKPFLKEWEDAHKDVEVEYTDKLLTPETVALAKGADGVVVYQQLDYTA ETLQALADNGITKMSLRNVGVDNIDMAKAKELGFQITNVPVYSPNAIAEHAAIQAARILR QDKAMDEKVARHDLRWAPTIGREVRDQVVGVIGTGHIGQVFMQIMEGFGAKVIAYDIFRN PELEKKGYYVDSLDDLYKQADVISLHVPDVPANVHMINDESIAKMKQDVVIVNVSRGPLV DTDAVIRGLDSGKIFGYAMDVYEGEVGIFNEDWEGKEFPDARLADLIARPNVLVTPHTAF YTTHAVRNMVVKAFDNNLELVEGKEAETPVKVG
Function	This enzyme has D-lactate dehydrogenase activity.
KEGG Pathway	Metabolic pathways (ldb01100 ) Microbial metabolism in diverse environments (ldb01120 ) Pyruvate metabolism (ldb00620 )

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Clinical Trial Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
DB-053072	DM1K248	N. A.	N. A.	Phase 1	[1]
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References

1	Cloning of D-lactate dehydrogenase genes of Lactobacillus delbrueckii subsp. bulgaricus and their roles in D-lactic acid production. 3 Biotech. 2017 Jul;7(3):194.