Details of Drug-Metabolizing Enzyme (DME)
General Information of Drug-Metabolizing Enzyme (DME) (ID: DEHYDG9)
| DME Name | Arylsulfate sulfotransferase (astA) | ||||
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| Synonyms | Arylsulfotransferase; Aryl sulfotransferase IV; Arylsulfotransferase; 1-naphthol phenol sulfotransferase; 2-naphtholsulfotransferase; 4-nitrocatechol sulfokinase; Aryl SULT; ArylST; astA | ||||
| Gene Name | astA | ||||
| UniProt ID | |||||
| INTEDE ID | |||||
| EC Number | EC: 2.8.2.22 | ||||
| Lineage | Species: Eubacterium rectale | ||||
| Tissue Distribution | Primarily distributed in human gut. | ||||
| Sequence |
MSVKYSFEDHIVNRQYEAEQEMLKEFEAGNYTIANPLVKYNAYLVNPLSAVVCFHTEKET
AITVTVLGKTPQGNISHTFPKAKKHVLPIVGLYSDYQNRVEIRAYRGESNIITIDVPDVF DGKEVIYSMDTTPEYLQDNIILVSPAGEDLAVGFDYAGDARWHMTIPCVFDVKRLKNGNL IMGSHRVIQMPYYMSGLYEISPCGKIYKEFRLPGGYHHDEFEMEDGNLLSLTDDLTSETV EDMCVLIDRNTGEILKTWDYKKFLDPKKVSKSGSWSDHDWFHNNAVWYDKNTNSLTFSGR HIDSMVNIDYETGELNWIIGDPEGWPEEMQKYFFKPVGNNFGWQYEQHACVITPDGDVMC FDNHHYGSKNPEKYLAARDNYSRGVRYKINTDDMTIEQVWQYGKDRGAEFFSPYICNVEY YNEGHYMVHSGGIAYDTEGNPSEALGAFAKDQGGRLESITVEICDNKKMLDLHVPGNYYR GEKLKLYSDGINLELGKGQILGEMGVTKEFDTEIPLEPSGEMLPESCNARIEDEIDRFTF FSRFEKGQLVMLLLEQGEEVHRYFISTTAVPFLAMCCGTFLDSDDRNTRTNINKTGLKGT YDLRVIIDDKKYETGVTISC |
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| Function | This enzyme catalyses the transfer of a sulfate group from a phenol sulfate ester to other phenolic compounds. It's activity is enhanced by Mg2+ and Mn2+. | ||||
Molecular Interaction Atlas (MIA) of This DME
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1 Approved Drug(s) Metabolized by This DME
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