Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEI2XLV)

• DME Name: Phosphoenolpyruvate carboxykinase (pckG)
• Synonyms: GTP-dependent phosphoenolpyruvate carboxykinase; PEP carboxykinase; GTP-PEPCK; PEPCK; SAMN04487832_102103; pckG
• Gene Name: pckG
• UniProt ID: A0A1K1UGV6_RUMFL
• INTEDE ID: DME1780
• EC Number:
  EC: 4.1.1.32
  Lyases
  Carbon-carbon lyase
  Carboxy-lyase
  EC: 4.1.1.32
• Lineage:
  Species: Ruminococcus flavefaciens
  Kingdom: Bacteria
  Phylum: Firmicutes
  Class: Clostridia
  Order: Clostridiales
  Family: Ruminococcaceae
  Genus: Ruminococcus
  Species: Ruminococcus flavefaciens
• Tissue Distribution: Primarily distributed in human gut.
• Sequence:
  MSLTKNPNVLKWVDEMVALCKPDNVVWIDGSKEQIDSLIEEVTSLPDDSWDKMYKLNPEK
  YPNCLYHRTRANDVARVEDRTFICSKEKSGAGPTNNWMAPDEMKALLTPMYDGVMKGRTM
  YVIPYSMGPIGSPLAKVGVEVTDSIYVVLNMNIMTRMGKQAFENLGDTSDDFVRGLHSKA
  DVDPEKRYIVQFPEENTIWSINSAYGGNVLLGKKCFALRIASFQGKNEAWMAEHMLILGV
  KKPNGDVKYITAAFPSACGKTNLAMLIPPEGYKKEGYEVFTVGDDIAWMKPGKDGRLYAI
  NPENGFFGVAPGTNEKSNYNALACTKNGAIFTNVALDNSDNTPWWEKLTENPPKDATEWK
  GEKVDGEAYTAAGNKLAHPNSRFTAPAQNCPCISPEFNNPEGVPVSAIIFGGRRATTAPL
  VYQSFDWTHGTYIGSAVSSETTAAATGAVGVLRHDPMAMKPFIGYNVGDYWAHWLEMGAR
  LGSKAPKIFNVNWFRTDDEGNFLWPGFGDNMRVIDWIIKRVENEVDAVETPIGYLPKPED
  INLKGIEDEVSADALKLLLTVNKDEWKKEIAEMRRYYDEDIKAKGGNIPQALYDELDMIE
  ANLNK
• Function: This enzyme catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.

Molecular Interaction Atlas (MIA) of This DME

1 Clinical Trial Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
FT-0624878	DMDKYVE	N. A.	N. A.	Phase 3	[1], [2]

References

• [1] Purification and characterization of phosphoenolpyruvate carboxykinase from the anaerobic ruminal bacterium Ruminococcus flavefaciens. Arch Microbiol. 1997 May;167(5):289-94.
• [2] The gut microbial community in metabolic syndrome patients is modified by diet. J Nutr Biochem. 2016 Jan;27:27-31.