Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEICTXP)

• DME Name: Sucrose-6-phosphate hydrolase scrB (ScrB)
• Synonyms: Sucrose-phosphate hydrolase B; Invertase B; Sucrase B; ANACAC_00495
• Gene Name: ScrB
• UniProt ID: B0MAC0_ANACD
• INTEDE ID: DME1542
• EC Number:
  EC: 3.2.1.26
  Hydrolases
  Glycosylase
  O/S-glycosyl compound glycosidase
  EC: 3.2.1.26
• Lineage:
  Species: Anaerostipes caccae
  Kingdom: Bacteria
  Phylum: Firmicutes
  Class: Clostridia
  Order: Clostridiales
  Family: Lachnospiraceae
  Genus: Anaerostipes
  Species: Anaerostipes caccae
• Tissue Distribution: Primarily distributed in human oral cavity.
• Sequence:
  MFKKYNKVLKEDYEKWYAEHESDREETAKDPMRLKFHLMPKTGWLNDPNGLCQFHGTYHI
  YYQYTPFEPTGELKLWGHYTTKDFISYIDEGPVLFPDSEFDAHGVYSGSAFVKGDTIHYF
  YTGNIKCFDRDDYDYINSGRGSNTIHVASKDGYHFSEKDLLMTTDDYPEDMSCHVRDPKI
  IRRGDDYYMVQGARDIDSHGLILMFHSKDLSHWEYFDRIVPKEPFGYMWECPDLFELDGQ
  MMLITCPQGVEPKGIDYQNVHQCTAVKMDYDFENKSYEICDNSEFQQLDRGFDFYAPQTF
  EDEKGRRILIGWMGIPDADYTNPTVEHGWQHALTIPRELHIKDGRIIQRPIKEMEQMRKG
  ELICTFSEQGRMESNLKLYEAEVRFRHCADMVLTLKEGVTLSYDSGLLTLDLGDFGEGRT
  TRCAALDELKDLRIFADTTSLEIFVNGGEEVFTTRVYSSQGKLSIDGDCSGTMKIYCLRP
  LEIGERE
• Function: This enzyme takes part in glucuronoside catabolic process. Substrates include sucrose.

Molecular Interaction Atlas (MIA) of This DME

1 Preclinical Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Kestose	DML93TN	N. A.	N. A.	Preclinical	[1]

1 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sucrose	DMVWUCF	Discovery agent	N.A.	Investigative	[1]

References

• [1] Characterization of fructooligosaccharide-degrading enzymes in human commensal Bifidobacterium longum and Anaerostipes caccae. Biochem Biophys Res Commun. 2019 Oct 15;518(2):294-298.