Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEINPMH)

DME Name	Lactate racemase (Lsa784)
Synonyms	Lactate racemization operon protein LarA; LAS9624_00840; LSAJ112_140075; Lar; Lsa784; lsa784
Gene Name	Lsa784
UniProt ID	Q3BCH3_LACSK
INTEDE ID	DME1198
Gene ID	33974450
EC Number	EC: 5.1.2.1 Isomerase Racemase/epimerase Hydroxy acid racemase/epimerase EC: 5.1.2.1
Lineage	Species: Lactobacillus sakei Kingdom: Bacteria Phylum: Firmicutes Class: Bacilli Order: Lactobacillales Family: Lactobacillaceae Genus: Lactobacillus Species: Lactobacillus sakei Subspecies: Lactobacillus sakei NRIC 1071(T)
Tissue Distribution	Primarily distributed in human gut.
Sequence	MVAIKLPYDQKIITANIADANFAGKLVSQAATYQNPLSEAETVEQSLDNPIDSPKLEELA KGKKNIVIISSDHTRPVPSHIMTPILLRRIRSVAPDARIRILVATGFHRPSTHEELVNKY GEEIVANEEIVMHISTDDSSVVKIGQLPSGGDCIINKIAVEADLLISEGFIESHFFAGFS GGRKSILPGVASYKTIMANHSGEFINSHYSRTGNLMHNPVHKDMVYAAKTAGLKFILNVV LDEDKHIIGSFAGNLETAHKKGCDFVESLSEVDKIDCDIAISTNGGYPLDQNIYQAVKGM TAAEATNKQGGVIIMVAGARDGHGGDGFYHNIADVKDPKEFLDQAINTPRLETVPDQWTS QILARILVQHHVIFVSDLVDPQLITDMHMELATSLDAALERAYAIEGADAKVTVIPDGLG VIVK
Function	This enzyme contains a unique nickel-containing cofactor, pyridinium-3-thioamide-5-thiocarboxylate mononucleotide Ni pincer complex.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
D-lactic acid	DMBNFQ8	Discovery agent	N.A.	Investigative	[1]
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References

1	The effect of sodium acetate on the growth yield, the production of L- and D-lactic acid, and the activity of some enzymes of the glycolytic pathway of Lactobacillus sakei NRIC 1071(T) and Lactobacillus plantarum NRIC 1067(T). J Gen Appl Microbiol. 2002 Apr;48(2):91-102.