Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEIRBUF)

DME Name	L-malate:NADP(+) oxidoreductase (maeB)
Synonyms	L-malate:NADP oxidoreductase; NADP-dependent malic enzyme; Bacterial NADP-ME
Gene Name	maeB
UniProt ID	MAO2_ECOLI
INTEDE ID	DME1471
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Gene ID	946947
EC Number	EC: 1.1.1.40 Oxidoreductase CH-OH donor oxidoreductase NAD/NADP oxidoreductase EC: 1.1.1.40
Lineage	Species: Hungateiclostridium thermocellum Kingdom: Bacteria Phylum: Firmicutes Class: Clostridia Order: Clostridiales Family: Hungateiclostridiaceae Genus: Hungateiclostridium Species: Hungateiclostridium thermocellum
Tissue Distribution	Primarily distributed in human gut.
Sequence	MDDQLKQSALDFHEFPVPGKIQVSPTKPLATQRDLALAYSPGVAAPCLEIEKDPLKAYKY TARGNLVAVISNGTAVLGLGNIGALAGKPVMEGKGVLFKKFAGIDVFDIEVDELDPDKFI EVVAALEPTFGGINLEDIKAPECFYIEQKLRERMNIPVFHDDQHGTAIISTAAILNGLRV VEKNISDVRMVVSGAGAAAIACMNLLVALGLQKHNIVVCDSKGVIYQGREPNMAETKAAY AVVDDGKRTLDDVIEGADIFLGCSGPKVLTQEMVKKMARAPMILALANPEPEILPPLAKE VRPDAIICTGRSDYPNQVNNVLCFPFIFRGALDVGATAINEEMKLAAVRAIAELAHAEQS EVVASAYGDQDLSFGPEYIIPKPFDPRLIVKIAPAVAKAAMESGVATRPIADFDVYIDKL TEFVYKTNLFMKPIFSQARKAPKRVVLPEGEEARVLHATQELVTLGLAKPILIGRPNVIE MRIQKLGLQIKAGVDFEIVNNESDPRFKEYWTEYFQIMKRRGVTQEQAQRALISNPTVIG AIMVQRGEADAMICGTVGDYHEHFSVVKNVFGYRDGVHTAGAMNALLLPSGNTFIADTYV NDEPDAEELAEITLMAAETVRRFGIEPRVALLSHSNFGSSDCPSSSKMRQALELVRERAP ELMIDGEMHGDAALVEAIRNDRMPDSSLKGSANILVMPNMEAARISYNLLRVSSSEGVTV GPVLMGVAKPVHVLTPIASVRRIVNMVALAVVEAQTQPL
Function	This enzyme catalyzes the oxidative decarboxylation of (S)-malate in the presence of NADP+ and divalent metal ions, and the decarboxylation of oxaloacetate.
KEGG Pathway	Carbon metabolism (ecj01200 ) Metabolic pathways (ecj01100 ) Microbial metabolism in diverse environments (ecj01120 ) Pyruvate metabolism (ecj00620 )

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This DME

1 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Malate	DMMCJLH	N. A.	N. A.	Investigative	[1], [2]
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References

1	Thermostable, ammonium-activated malic enzyme of Clostridium thermocellum. Biochim Biophys Acta. 1981 Aug 13;660(2):251-5.
2	The correlation between Clostridium-difficile infection and human gut concentrations of Bacteroidetes phylum and clostridial species. Eur J Clin Microbiol Infect Dis. 2014 Mar;33(3):377-83.