Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEJ01UG)

DME Name Arylamine N-acetyltransferase (NAT)
Synonyms N-hydroxyarylamine O-acetyltransferase; nhoA; Arylamine N-acetyltransferase/N-hydroxyarylamine O-acetyltransferase; Arylhydroxamate N,O-acetyltransferase; NAT101; STM1582
Gene Name nhoA
UniProt ID
NHOA_SALTY
INTEDE ID
DME1111
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Gene ID
1253100
EC Number EC: 2.3.1.5
Transferase
Acyltransferase
Acyltransferase
EC: 2.3.1.5
Lineage Species: Salmonella enterica
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Salmonella
Species: Salmonella enterica
Tissue Distribution Primarily distributed in human gut.
Sequence
MTSFLHAYFTRLHCQPLGVPTVEALRTLHLAHNCAIPFENLDVLLPREIQLDETALEEKL
LYARRGGYCFELNGLFERALRDIGFNVRSLLGRVILSHPASLPPRTHRLLLVDVEDEQWI
ADVGFGGQTLTAPLRLQAEIAQQTPHGEYRLMQEGSTWILQFRHHEHWQSMYCFDLGVQQ
QSDHVMGNFWSAHWPQSHFRHHLLMCRHLPDGGKLTLTNFHFTRYHQGHAVEQVNVPDVP
SLYQLLQQQFGLGVNDVKHGFTEAELAAVMAAFDTHPEAGK
Function
This enzyme catalyzes both the acetyl-CoA-dependent N-acetylation of aromatic amines and the O-acetylation of N-hydroxyarylamines. And in vitro, it catalyzes the O-acetylation of N-hydroxy-Glu-P-1, and the N-acetylation of isoniazid and 2-aminofluorene.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DME
1 Investigative Drug(s) Metabolized by This DME
Drug Name Drug ID Indication ICD 11 Highest Status REF
Asacolitin DM3WVPJ N. A. N. A. Investigative [1]

References

1 Identification and functional characterization of arylamine N-acetyltransferases in eubacteria: evidence for highly selective acetylation of 5-aminosalicylic acid. J Bacteriol. 2001 Jun;183(11):3417-27.