Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEJADS9)

DME Name	Aminoglycoside N-acetyltransferase (aacC2)
Synonyms	Aminoglycoside N(6')-acetyltransferase type 1; Aminoglycoside resistance protein; AAC(6')-Ih
Gene Name	aacC2
UniProt ID	AAC6_ACIBA
INTEDE ID	DME1172
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Gene ID	23000000
EC Number	EC: 2.3.1.82 Transferase Acyltransferase Acyltransferase EC: 2.3.1.82
Lineage	Species: Acinetobacter baumannii Kingdom: Bacteria Phylum: Proteobacteria Class: Gammaproteobacteria Order: Pseudomonadales Family: Moraxellaceae Genus: Acinetobacter Species: Acinetobacter baumannii
Tissue Distribution	Primarily distributed in human lung.
Sequence	MNIMPISESQLSDWLALRCLLWPDHEDVHLQEMRQLITQAHRLQLLAYTDTQQAIAMLEA SIRYEYVNGTQTSPVAFLEGIFVLPEYRRSGIATGLVQQVEIWAKQFACTEFASDAALDN QISHAMHQALGFHETERVVYFKKNIG
Function	This enzyme catalyzes the transfer of an acetyl group from acetyl-CoA to the 6'-amino group of aminoglycoside molecules conferring resistance to antibiotics containing the purpurosamine ring including amikacin, kanamycin, tobramycin and netilmicin.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

3 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Framycetin	DMF8DNE	Acute liver failure	DB91	Approved	[1]
Netilmicin	DMRD1QK	Bacterial infection	1A00-1C4Z	Approved	[1]
Tobramycin	DMUI0CH	Bacteremia	1A73	Approved	[1]
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References

1	Relationship between antimicrobial resistance and aminoglycoside-modifying enzyme gene expressions in Acinetobacter baumannii. Chin Med J (Engl). 2005 Jan 20;118(2):141-5.