Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEJOCPK)

DME Name	Homogentisate 1,2-dioxygenase (hmgA)
Synonyms	Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase; HGD; VPARA_16900; hmgA
Gene Name	hmgA
UniProt ID	A0A0H2M8H5_VARPD
INTEDE ID	DME1520
EC Number	EC: 1.13.11.5 Oxidoreductase Oxygen single donor oxidoreductase Oxygen single donor oxidoreductase EC: 1.13.11.5
Lineage	Species: Variovorax paradoxus Kingdom: Bacteria Phylum: Proteobacteria Class: Betaproteobacteria Order: Burkholderiales Family: Comamonadaceae Genus: Variovorax Species: Variovorax paradoxus Subspecies: Variovorax paradoxus VP-5
Tissue Distribution	Primarily distributed in human oral cavity.
Sequence	MANPIDNAERRYQSGFGNEYASEAIAGALPQGRNSPQRAPFDLYTELLSGTAFTAPRHEN RRTWLYRRQPSVVSGRYQPYAQAHWTTGADREIALPPEPLRWHPLPLDGAAEVDFIDGMH TLAANGDAESQVGIGSLMYLAGRSMERRAFVNADGEMLIVPQQGRLVITTELGVLDVKPG EIALLPRGMAFKVALPDSDAGAGPSRGYVCENYGAQFRLPELGPIGSNGLANARDFQAPV AAFEEDGGAYELVKKFGGRFWKAPTKQSPFNVVAWHGNLAPVKYDTANFMVIGSISFDHP DPSIFTVLTSPSDTPGTANCDFVIFPPRWMVMENTFRPPWFHRNLMSEFMGLVLGEYDAK PGGFKPGGASLHNCMVPHGPDGEAFDKATHADLKPHKLDNTLAFMFESRYRFIPTNFALR SPALDTDYADCWAGLNDQFKA
Function	This enzyme requires Fe2+ to display activity.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Homovanillic acid	DM0SHPY	N. A.	N. A.	Investigative	[1], [2]
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References

1	Isolation and molecular detection of methylotrophic bacteria occurring in the human mouth. Environ Microbiol. 2005 Aug;7(8):1227-38.
2	Degradation of homovanillate by a strain of Variovorax paradoxus via ring hydroxylation. FEMS Microbiol Lett. 1995 Dec 15;134(2-3):213-9.