Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEJRWQ6)

DME Name	Alpha-galactosidase (melA)
Synonyms	Alpha-D-galactoside galactohydrolase; 1,6-alpha-D-galactoside galactohydrolase; Galactosidase alpha; Ag-I; Ag-II; Aga-F78; Aga-Y; AgaA; agaAJB13; AgaB; AgaI; LBA1438; LaMel36A; aga; melA
Gene Name	melA
UniProt ID	MELA_LACAC
INTEDE ID	DME1714
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Gene ID	3252915
EC Number	EC: 3.2.1.22 Hydrolases Glycosylase O/S-glycosyl compound glycosidase EC: 3.2.1.22
Lineage	Species: Lactobacillus acidophilus Kingdom: Bacteria Phylum: Firmicutes Class: Bacilli Order: Lactobacillales Family: Lactobacillaceae Genus: Lactobacillus Species: Lactobacillus acidophilus
Tissue Distribution	Primarily distributed in human gut.
Sequence	MTSNLIKFDDQNKVFHLHNKQISYLLSIEDGGTLSHLYFGGAVKNYNNQLKYPRLDRGFS GNLPESLDRTFSRDSLPKEYSSAGEMDFHTPATIVRNPDGSNALFLAYKSYKIEDGKPDL KGLPHSWTKEDDEAQTLIVTLEDKVSKLEYDLLYTIYRDRPVIVRSVQVHNHGEEAVYLE KVASMQMDYVDKDFEVITLPGAHANERRVQRENIGQGIKVFSSYRGTSSHQMNPFMALVD HDTNEFMGEAYGFALAYSGNHKFEVERDQFGQIHVNTGINDYNFKWKLNPNEEFQTPEVL MVYSDQGLNKMSQAFHSLIHERIMRSKFKDQIRPVLVNNWEATYFDFNEDKLKTIVDKAK KLGLEMFVLDDGWFGHRDDDNSSLGDWKVYKKKFPNGLGHFADYVHEQGLKFGLWFEPEM ISYESNLYKEHPDYLMHVPGRKPCPSRNQYVLELGRKEVRDNIFEQMVKILDSKKIDYIK WDMNRSLSDIYESDLPADQQGEAYHRYVLGYYDLLNKLVTRYPDILFEGCSGGGGRFDVG QAYYTPQIWASDNTDAIERLKIQYGTSLVYPQSMMTSHVSVSPNEQNGRITPFNTRGAVA MWGDLGYELDLTKMSDEESDQVVKQVTEYKKIREVTQFGTLYRLKASASNQCAWMMVDSN KNEAVVTVVNVMAHAQPYCTKTKLAGLDPDKRYKNLETDEVFGGDELMHLGFYDPIERGD FKAKMYHFKAIN
Function	This enzyme hydrolyzes alpha-D-fucosides and the short-chain alpha-galactosaccharide raffinose.
KEGG Pathway	Galactose metabolism (lac00052 ) Glycerolipid metabolism (lac00561 ) Metabolic pathways (lac01100 ) Sphingolipid metabolism (lac00600 )

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This DME

1 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Raffinose	DMVHDOS	N. A.	N. A.	Investigative	[1]
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References

1	Crystal structure of alpha-galactosidase from Lactobacillus acidophilus NCFM: insight into tetramer formation and substrate binding. J Mol Biol. 2011 Sep 23;412(3):466-80.