Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEKI69B)

• DME Name: Alpha-galactosidase (melA)
• Synonyms: Alpha-D-galactoside galactohydrolase; 1,6-alpha-D-galactoside galactohydrolase; Galactosidase alpha; Ag-I; Ag-II; Aga-F78; Aga-Y; AgaA; agaAJB13; AgaB; AgaI; FIU77_02220
• Gene Name: melA
• UniProt ID: A0A5P0VEV3_LACBU
• INTEDE ID: DME2077
• EC Number:
  EC: 3.2.1.22
  Hydrolases
  Glycosylase
  O/S-glycosyl compound glycosidase
  EC: 3.2.1.22
• Lineage:
  Species: Lactobacillus buchneri
  Kingdom: Bacteria
  Phylum: Firmicutes
  Class: Bacilli
  Order: Lactobacillales
  Family: Lactobacillaceae
  Genus: Lactobacillus
  Species: Lactobacillus buchneri
• Tissue Distribution: Primarily distributed in human gut.
• Sequence:
  MAIRIEDQNLLFHLQTDHTSYIFHMMENGELGQIYYGKRVHSKPSYDNLVTREWHNAAAV
  WRLDHKDVQPQVLKQEYASLGKGDFRYPAYQVAQANGSRITEFKYESYELVDGKQRLAGL
  PSAFDDTDDDAQTLTIALRDKLLGLVMHLNYTIFPHQDVIVRSAEFQNQGNEKLRLNSAA
  SAQLDLPDADYDFIQFSGAWARERHMIRTHLRSGVQSVGSLRGTSSHQQNPFVMLARPNT
  DDAQGSVFGFNLIYSGNFSDQVQVDQYDASRVLVGINPEEFAWNLKPGDKFQTPEAVLSY
  TDAGMNQLSQQMGAFYQDHLVNPRFAHEQRPTLINNWEATFMDFDEDKLLSFATTAKKLG
  LEMFVLDDGWFGHRNNDDSSLGDWFVNEPKFPSGFGTFTQKIHDLGLKFGLWFEPEMISI
  DSELYKQHPDWLINAPGRHASPERQQFVLDMTRSEVVDYLFDAMSKIIEMTKLDYIKWDM
  NRNITETYSSQLSADDQLEVPHRYILGVYQLYDRLVKAYPDVLFESCSSGGGRFDLGMMY
  YAPQAWTSDDTDAVERMLIQFGTSYGYPQTMMGAHVSAVPNDQVGRITSLKTRANVAYFG
  DFGYELDITKMSPEEQQQVKEQTAFYKEHRQLFQFGKFYRIDNPFANGGNVMSWEVVSDD
  QKHAIAARYQILNRPNTGYIRLYLKGLDPDTKYTVNGGSEQFYGDELMNAGLFVSDILHE
  THGTDQSADFNSKLFVIDAVK
• Function: This enzyme hydrolyzes alpha-D-fucosides.

Molecular Interaction Atlas (MIA) of This DME

1 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Melibiose	DMTKLH8	N. A.	N. A.	Investigative	[1]

References

• [1] Alpha-glactosidase activity of lactobacilli. Appl Microbiol. 1973 Nov;26(5):783-8.