Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEKVGPX)

DME Name	Retro-nitroreductase (rNR)
Synonyms	Retro-FMN reductase (NAD(P)H); Retro-FMN reductase NADPH; ECL_03157
Gene Name	rNR
UniProt ID	A0A0H3CM55_ENTCC
INTEDE ID	DME1584
Gene ID	9125636
EC Number	EC: 1.5.1.34 Oxidoreductase CH-NH donor oxidoreductase NAD/NADP acceptor oxidoreductase EC: 1.5.1.34
Lineage	Species: Enterobacter cloacae Kingdom: Bacteria Phylum: Proteobacteria Class: Gammaproteobacteria Order: Enterobacterales Family: Enterobacteriaceae Genus: Enterobacter Species: Enterobacter cloacae
Tissue Distribution	Primarily distributed in human gut.
Sequence	MDIISVALKRHSTKAFDPAKKLTADEAEKIKTLLQYSPSSTNSQPWHFIVASTEEGKARV AKSAAGTYVFNERKMLDASHVVVFCAKTAMDDAWLERVVDQEEADGRFNTPEAKAANHKG RTYFADMHRVDLKDDDQWMAKQVYLNVGNFLLGVAALGLDAVPIEGFDAAILDEEFGLKE KGFTSLVVVPVGHHSVEDFNATLPKSRLPLSTIVTEC
Function	This enzyme uses NADH as source of reducing equivalents to reduce of a variety of nitroaromatic compounds.
KEGG Pathway	Microbial metabolism in diverse environments (enc01120 ) Nitrotoluene degradation (enc00633 )

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Clinical Trial Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AI3-23606	DMHMT49	N. A.	N. A.	Phase 1	[1]
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2 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BENZOQUINONE	DMNBA0G	Discovery agent	N.A.	Investigative	[1]
Nitroimidazole	DMMY2S5	Trypanosomiasis	1D51-1F53	Investigative	[1]
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References

1	Retro-nitroreductase, a putative evolutionary precursor to Enterobacter cloacae strain 96-3 nitroreductase. Antioxid Redox Signal. 2001 Oct;3(5):747-55.