Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEL4UKY)

DME Name	Methylenetetrahydrofolate dehydrogenase (folD)
Synonyms	Methenyltetrahydrofolate cyclohydrolase; Bifunctional protein FolD; C3R19_22270; PMF13cell1_04275; folD
Gene Name	folD
UniProt ID	A0A2S4GHV2_9FIRM
INTEDE ID	DME1333
EC Number	EC: 1.5.1.5 Oxidoreductase CH-NH donor oxidoreductase NAD/NADP acceptor oxidoreductase EC: 1.5.1.5
Lineage	Species: Blautia producta Kingdom: Bacteria Phylum: Firmicutes Class: Clostridia Order: Clostridiales Family: Lachnospiraceae Genus: Blautia Species: Blautia producta
Tissue Distribution	Primarily distributed in human gut.
Sequence	MAKRLLGKEVTAALNERIKADVAALEEKGVKPTLCIIRVGENESDISYERGATKRCETLG VACEKILLPADVSQEELLATIDKVNKDDKIHGVLLFRPLPKHLNQSVIENALDPAKDVDC MTDGSMSGVFTGKNVGFPPCTPQACMEILDFYGIDCTGKKAVVVGRSLVVGKPAAMMLIK KNATVTICHTRTVDMPSVVREADIVIVAAGRAGVIDDTYLSAGQTVIDVGINVNAEGKLC GDVDFEKAEPVVDAITPVPGGVGSVTTSVLVGHVVEAAKRKFA
Function	This enzyme catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
KEGG Pathway	Carbon metabolism (bpro01200 ) Metabolic pathways (bpro01100 ) Microbial metabolism in diverse environments (bpro01120 ) One carbon pool by folate (bpro00670 )

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Clinical Trial Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ISO-901	DMBQ8CA	N. A.	N. A.	Phase 1	[1], [2]
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References

1	Purification and characterization of NADP(+)-dependent 5,10-methylenetetrahydrofolate dehydrogenase from Peptostreptococcus productus marburg. J Bacteriol. 1991 Feb;173(4):1414-9.
2	Characterization of NAD-dependent 3 alpha- and 3 beta-hydroxysteroid dehydrogenase and of NADP-dependent 7 beta-hydroxysteroid dehydrogenase from Peptostreptococcus productus. Biochim Biophys Acta. 1989 Aug 8;1004(2):230-8.