Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEM1BHT)

DME Name	Azoreductase (azoR)
Synonyms	Azo-dye reductase; FMN-dependent NADH-azo compound oxidoreductase; FMN-dependent NADH-azoreductase; azoR; A5810_000531; AS238_04965; B1P95_03410; BU183_03850; BU187_02260; BU190_11865; BU192_09835; BXT96_08720; CQR37_06980; CUM68_06655; CUN04_07390; DJ550_05610; DKP91_06820; DRZ84_07550; DTPHA_1403160; DTPHA_601027; EB63_02313; EWH22_12905; F6439_02410; F6440_11520; NCTC13923_00920; acpH
Gene Name	acpH
UniProt ID	A0A132Z973_ENTFC
INTEDE ID	DME1345
EC Number	EC: 1.7.1.6 Oxidoreductase Cytochrome acceptor oxidoreductase NAD/NADP acceptor oxidoreductase EC: 1.7.1.6
Lineage	Species: Enterococcus faecium Kingdom: Bacteria Phylum: Firmicutes Class: Bacilli Order: Lactobacillales Family: Enterococcaceae Genus: Enterococcus Species: Enterococcus faecium
Tissue Distribution	Primarily distributed in human gut.
Sequence	MASVLVVKGHPLTAEESRTVKALTSFLTSYKENHPDDEVTVLELYRDDIPEIDEELLSGW EALRAGAEFTSLSESQQQKIARFNELTDQFLAADKIVIANALWNLNIPTKLKAWFDTVNV AGKTFRYTENGPEGLVTGKKALHIQSNGGVYNGQDFASQYVKGILNFVGIDQVDQLFIEG IDYDPDRADELMQNALDKAAALGKSF
Function	This enzyme catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. And it requires NADH, but not NADPH, as an electron donor for its activity.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[1], [2]
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References

1	The influence of probiotic treatment on sulfasalazine metabolism in rat. Xenobiotica. 2012 Aug;42(8):791-7.
2	Developing a metagenomic view of xenobiotic metabolism. Pharmacol Res. 2013 Mar;69(1):21-31.