Details of Drug-Metabolizing Enzyme (DME)
General Information of Drug-Metabolizing Enzyme (DME) (ID: DEME01W)
| DME Name | Molybdopterin-dependent enzyme (molD) | ||||
|---|---|---|---|---|---|
| Synonyms | Molybdopterin-dependent oxidoreductase; Oxidoreductase molD; molD | ||||
| Gene Name | molD | ||||
| UniProt ID | |||||
| INTEDE ID | |||||
| EC Number | EC: 1.1.1.40 | ||||
| Lineage | Species: Escherichia coli | ||||
| Tissue Distribution | Primarily distributed in human gut. | ||||
| Sequence |
MNPPEEDPGTPEPRIGPVPEKKPAFRPYHHPAAGWGAAKSVTRFLTKERELIDGPRAIAK
MNHENGGFDCPGCAWPDDIKGLKLDICENGIKHVTWEMTRKRVGREFFAAHSVSELSGWS DFRLEDQGRLTEPMVYDPESDHYEPISWKDAFELVGRTLRGLDSPHQASFYTSGRLGNEA TFLYQLWARELGTNNLPDCSNMCHEASGRALQAALGTGKGTCDLKDWESADALFIMGVNA ASNAPRMLTALAEAYRRGAQVVHVNPLVEAAATRTIIPHDIADMAMFKSTRTSTLNLQVR IGGDMAFLRGVAKAVLKQAETDPKALDREFIDRYTDGFDAYRALCEATGWDEIERQSGLS RDAVLAAARVYGEADRSIISWCLGVTQHDHGVDTIREIVNVLLLRGNLGREGAGPSPVRG HSNVQGNRTCGINHRPPEEFLDRLADACGIEPPREHGLDTVGTIRAMHDGDVKVFVGMGG NFALAAPDTPYTYEALRNCDLTVQVSTKLNRSHLVHGRAALILPCLGRTEKDEQRAGLQS TSVEDSMSMVHLSVGMKRPASRHLLSEPAIIAGMARATLPGSSTPWEWYVEDYDRIRDSM ARVVEGFEDCNRRVRLPLGFRIRQPARELVFMTESGRAEFSTAPLPDVVPEPGTLALGTM RSHDQWNTTIYSDDDRYRGITNLRTLVFMNKDDMRERGVEEFGPVDITSTARDGSRRRVE GYLAVPYDIPRGCAAGYMPEMNVLCALVDYSTQSDQPLMKHVKVTITPSG |
||||
| Function | This enzyme catalyzes the conversion of doxorubicin to 7-deoxydoxorubicinol and 7-deoxydoxorubicinolone via a reductive deglycosylation mechanism. | ||||
Molecular Interaction Atlas (MIA) of This DME
| Molecular Interaction Atlas (MIA) | ||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
1 Approved Drug(s) Metabolized by This DME
|
||||||||||||||||||||||||||||