Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEMVXEA)

DME Name	Phosphotransferase enzyme strA (strA)
Synonyms	Streptomycin phosphotransferase strA; Bacterial phosphotransferase strA; strA
Gene Name	strA
UniProt ID	Q79DN3_ERWAM
INTEDE ID	DME2102
Gene ID	40045105
EC Number	EC: 2.7.3.9 Transferase Kinase Phosphotransferase EC: 2.7.3.9
Lineage	Species: Erwinia amylovora Kingdom: Bacteria Phylum: Proteobacteria Class: Gammaproteobacteria Order: Enterobacterales Family: Erwiniaceae Genus: Erwinia Species: Erwinia amylovora
Tissue Distribution	Primarily distributed in human gut.
Sequence	MNRTNIFFGESHSDWLPVRGGESGDFVFRRGDGHAFAKIAPASRRGELAGERDRLIWLKG RGVACPEVINWQEEQEGACLVITAIPGVPAADLSGADLLKAWPSMGQQLGAVHSLSVDQC PFERRLSRMFGRAVDVVSRNAVNPDFLPDEDKSTPQLDLLARVERELPVRLDQERTDMVV CHGDPCMPNFMVDPKTLQCTGLIDLGRLGTADRYADLALMIANAEENWAAPDEAERAFAV LFNVLGIEAPDRERLAFYLRLDPLTWG
Function	This enzyme is enzyme I of the phosphotransferase system, and it acts only on histidine residues in specific phosphocarrier proteins of low molecular mass (9.5 kDa) involved in bacterial sugar transport.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Streptomycin	DME1LQN	Bacterial infection	1A00-1C4Z	Approved	[1]
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References

1	Genetic analysis of streptomycin-resistant (Sm(R)) strains of Erwinia amylovora suggests that dissemination of two genotypes is responsible for the current distribution of Sm(R) E. amylovora in Michigan. Phytopathology. 2011 Feb;101(2):182-91.