Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DENLBG3)

DME Name	Azoreductase (azoR)
Synonyms	Azo-dye reductase; FMN-dependent NADH-azo compound oxidoreductase; FMN-dependent NADH-azoreductase; azoR; BSIG_4687; Btheta7330_01816
Gene Name	azoR
UniProt ID	A0A0P0ETC6_BACT4
INTEDE ID	DME1474
EC Number	EC: 1.7.1.6 Oxidoreductase Cytochrome acceptor oxidoreductase NAD/NADP acceptor oxidoreductase EC: 1.7.1.6
Lineage	Species: Bifidobacterium animalis Kingdom: Bacteria Phylum: Actinobacteria Class: Actinobacteria Order: Bifidobacteriales Family: Bifidobacteriaceae Genus: Bifidobacterium Species: Bifidobacterium animalis Subspecies: Bifidobacterium animalis subsp. lactis B94
Tissue Distribution	Primarily distributed in human gut.
Sequence	MDRKGFLKSTMIATGSLLLGGAGICRFLNDKEPADGPFPRTIEKIHCGNMKKVLVIMSAG TKLGNTDRLTDAYIKGLVERGHSVTKVYLGSMRIEGCRGCGVCQRLAHQCAVRDGMQDIY PLFAECDTVVMASPLYFWTITSQLKAFIDRLYAISADDKYPQKDTVLLMTAGDDNENTFD QPKQYFRLLSQALGWNEVGIYCAGGCTGCEKLARQIDKVHLENVYKMGLEL
Function	This enzyme catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[1], [2]
------------------------------------------------------------------------------------

References

1	The influence of probiotic treatment on sulfasalazine metabolism in rat. Xenobiotica. 2012 Aug;42(8):791-7.
2	Developing a metagenomic view of xenobiotic metabolism. Pharmacol Res. 2013 Mar;69(1):21-31.