Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEOMLHG)

DME Name	Beta-hydroxysteroid dehydrogenase (hdhB)
Synonyms	Oxidoreductase short chain dehydrogenase/reductase family protein; COLAER_02088
Gene Name	hdhB
UniProt ID	A4ECA9_9ACTN
INTEDE ID	DME1189
Gene ID	42685322
EC Number	EC: 1.1.1.201 Oxidoreductase CH-OH donor oxidoreductase NAD/NADP oxidoreductase EC: 1.1.1.201
Lineage	Species: Collinsella aerofaciens Kingdom: Bacteria Phylum: Actinobacteria Class: Coriobacteriia Order: Coriobacteriales Family: Coriobacteriaceae Genus: Collinsella Species: Collinsella aerofaciens
Tissue Distribution	Primarily distributed in human gut.
Sequence	MNLREKYGEWGLILGATEGVGKAFCEKIAAGGMNVVMVGRREEKLNVLAGEIRETYGVET KVVRADFSQPGAAETVFAATEGLDMGFMSYVACLHSFGKIQDTPWEKHEAMINVNVVTFL KCFHHYMRIFAAQDRGAVINVSSMTGISSSPWNGQYGAGKAFILKMTEAVACECEGTGVD VEVITLGTTLTPSLLSNLPGGPQGEAVMKIALTPEECVDEAFEKLGKELSVIAGQRNKDS VHDWKANHTEDEYIRYMGSFYRD
Function	This enzyme catalyzes the oxidation of the 7beta-hydroxy group of bile acids such as ursodeoxycholate.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

2 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dehydrocholic acid	DMFK8Y9	Constipation	DD91.1	Approved	[1]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[1]
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References

1	Identification, cloning, heterologous expression, and characterization of a NADPH-dependent 7beta-hydroxysteroid dehydrogenase from Collinsella aerofaciens. Appl Microbiol Biotechnol. 2011 Apr;90(1):127-35.