Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEOS3FD)

• DME Name: Glutathione peroxidase 6 (GPX6)
• Synonyms: Cellular glutathione peroxidase; 3,3'-telluro-bis(proapne-3,1-diyl)adamantane carboxylate; ADA-Te-OH; ARMEP24; AtGPX1; ATGPX3; c-GPx4; GPX6; GPx-6; GSHPx-6
• Gene Name: GPX6
• UniProt ID: GPX6_HUMAN
• INTEDE ID: DME0610
• Gene ID: 257202
• EC Number:
  EC: 1.11.1.9
  Oxidoreductase
  Peroxidase
  Peroxidase
  EC: 1.11.1.9
• Lineage:
  Species: Homo sapiens
  Kingdom: Metazoa
  Phylum: Chordata
  Class: Mammalia
  Order: Primates
  Family: Hominidae
  Genus: Homo
  Species: Homo sapiens
• Sequence:
  MFQQFQASCLVLFFLVGFAQQTLKPQNRKVDCNKGVTGTIYEYGALTLNGEEYIQFKQFA
  GKHVLFVNVAAYUGLAAQYPELNALQEELKNFGVIVLAFPCNQFGKQEPGTNSEILLGLK
  YVCPGSGFVPSFQLFEKGDVNGEKEQKVFTFLKNSCPPTSDLLGSSSQLFWEPMKVHDIR
  WNFEKFLVGPDGVPVMHWFHQAPVSTVKSDILEYLKQFNTH
• Function: This enzyme has glutathione peroxidase activity and peroxidase activity.
• KEGG Pathway:
  Amyotrophic lateral sclerosis (ALS) (hsa05014)
  Arachidonic acid metabolism (hsa00590)
  Glutathione metabolism (hsa00480)
  Huntington's disease (hsa05016)
  Metabolic pathways (hsa01100)
  Thyroid hormone synthesis (hsa04918)
• Reactome Pathway: Detoxification of Reactive Oxygen Species (R-HSA-3299685)

Molecular Interaction Atlas (MIA) of This DME

1 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[1]

References

• [1] Metabolomics reveals a role for the chromatin-binding protein HMGN5 in glutathione metabolism. PLoS One. 2014 Jan 2;9(1):e84583.