Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEPB9C2)

• DME Name: Glycosyl hydrolase (glyH)
• Synonyms: Glycosidase; Glycoside hydrolase; Furcatin hydrolase; Isoflavonoid 7-O-apiosylglucosidase; NCTC7914_04276; bglB
• Gene Name: bglB
• UniProt ID: A0A379KQ43_PSEPU
• INTEDE ID: DME2062
• EC Number:
  EC: 3.2.1.18
  Hydrolases
  Glycosylase
  O/S-glycosyl compound glycosidase
  EC: 3.2.1.18
• Lineage:
  Species: Pseudomonas putida
  Kingdom: Bacteria
  Phylum: Proteobacteria
  Class: Gammaproteobacteria
  Order: Pseudomonadales
  Family: Pseudomonadaceae
  Genus: Pseudomonas
  Species: Pseudomonas putida
• Tissue Distribution: Primarily distributed in human gut.
• Sequence:
  MKHFKQAVSLMALGVMQASGALAAGPATGNEVEARVSSILDNMNQAEKINFTRVNDGHMI
  PSLLKWGIQGTVAYDSSMGVHVNNATFGAQYPSQSALAATWSINRAKEFGLAIAYETRIS
  GGQQMLSPGVNLYRTPYNGRSAEYVSGEDPFLGAVLAPAIVNGIQAQGIQASGKHYLANE
  QEANRQAVNVVADERTLRELYLPGFESMVKNANVASIMCGFNKVNGDYACENHHLITEVL
  KGEWGYQGTVISDFNAIHDPFKGAWAGTDLDMPSGLQFTEANLLPYLWSGQLTQNVIDDK
  VKRNLRAVVSYDFQENLNTAKTLEHTEYGQRASLNAAREGIVLLRNADTAAGKPLLPLAR
  TARIAVIGDWANQAPASPFGTANSPPNSYVTELSGLQQLASNSANVTYLSALSLNPKAAV
  WYQPTSSGSGVSNAGVKAEYFSNTSLSGDPVLTRIEPGVNLNWTTSTNETSTGTTAVSGF
  SPTAGAFSARFSATIKPTVSGAHVFKVRADGPYKLWVDGKLVVQSDGVPYSSDVVNALTT
  SGKSAALVAGKSYNVKLEYRRVQGNFTPALGGLAGVQMSWASLRPPKDIASYDAVVIAAG
  TNYENEGEGSDHGYALPDQQAELIKFVTKANPNTIVVTHGGGVADMQPWAKKVGAALHAW
  FPGQQGGQALAEILYGKVNPSGKLPVTIDKKIEDNPSYASYPDPAAYRGDNPLTEIDYSE
  GLYMGYRGYDKKHAKPLYPFGFGLSYTTFGYSDLKLSTNVMTPGNTVNATFTLTNTGDKA
  GFEVAQLYIQPIAPQVDRPKKELKGFTKVYLEPGQSKTVSLPIDSRSLAYFVQNTDSWDV
  DAGKFKVWVGPDSENLTLQRTLVTLMPQHLTTRDSNPLPAPLQAAVQVSDSQAY
• Function: This enzyme has wide specificity for beta-D-glucosides such as beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, beta-D-fucosides.

Molecular Interaction Atlas (MIA) of This DME

1 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lactulose	DMSAOWQ	Constipation	DD91.1	Approved	[1]

References

• [1] In vitro fermentation of lactulose by human gut bacteria. J Agric Food Chem. 2014 Nov 12;62(45):10970-7.