Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEPR1Y7)

DME Name	Beta-galactosidase (bgaB)
Synonyms	Beta-galactosidase/glucuronidase; Beta-galactosidase BgaBeta; Beta-Gal II; Beta-gal; BAD_1401; bgaB; bgaLII
Gene Name	bgaB
UniProt ID	BGAL_BIFAA
INTEDE ID	DME1140
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Gene ID	4557550
EC Number	EC: 3.2.1.23 Hydrolases Glycosylase O/S-glycosyl compound glycosidase EC: 3.2.1.23
Lineage	Species: Bifidobacterium adolescentis Kingdom: Bacteria Phylum: Actinobacteria Class: Actinobacteria Order: Bifidobacteriales Family: Bifidobacteriaceae Genus: Bifidobacterium Species: Bifidobacterium adolescentis Subspecies: Bifidobacterium adolescentis DSM 20083 Subspecies: Bifidobacterium adolescentis YIT 4011(T)
Tissue Distribution	Primarily distributed in human gut.
Sequence	MSARRNFEWPELLTADGRGIAFGGDYNPDQWSEDIWDDDIRLMKQAGVNTVALAIFSWDR IQPTEDRWDFGWLDRIIDKLGNAGIVVDLASATATAPLWLYESHPEVLPRDKYGHPVNAG SRQSWSPTSPVFKEYALTLCRKLAERYGTNPYVTAWHMGNEYGWNNREDYSDNALEAFRA WCRRKYGTIDALNQAWGTTFWGQEMNGFDEVLIPRFMGADSMVNPGQKLDFERFGNDMLL DFYKAERDAIAEICPDKPFTTNFMVSTDQCCMDYAAWAKEVNFVSNDHYFHEGESHLDEL ACSDALMDSLALGKPWYVMEHSTSAVQWKPLNTRKRKGETVRDSLAHVAMGADAINFFQW RASAFGAEAFHSAMVPHAGEDTKLFRQVCELGASLHTLADAGVQGTELAHSDTAILFSAE SEWATRSQTLPSMKLNHWHDVRDWYRAFLDAGSRADIVPLAYDWSSYKTVVLPTVLILSA ADTQRLADFAAAGGRVVVGYATGLIDEHFHTWLGGYPGAGDGLLRSMLGVRGEEFNILGA EAEGEPGEIRLSSADDSAALDGTTTRLWQNDVNVTGEHAQVLATYAGEEADEWELDGTAA VTRNPYGSGEAYFVGCDLDVADLTKLVRAYLAASSQENADVLHTVRASADATFDFYLPRG KKTVELQGIEGEPVILFQTDREEKPGSYTVRRNGVLVVRR
Function	This enzyme is involved in the hydrolysis of transgalactooligosaccharides.
KEGG Pathway	Galactose metabolism (bad00052 )

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This DME

1 Clinical Trial Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
LS-71719	DM0TZPL	N. A.	N. A.	Phase 2	[1]
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1 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PNA-D-glucopyranoside	DMPUC8I	N. A.	N. A.	Investigative	[2]
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References

1	Diverse galactooligosaccharides consumption by bifidobacteria: implications of beta-galactosidase--LacS operon. Biosci Biotechnol Biochem. 2015;79(4):664-72.
2	Beta-galactosidase from Bifidobacterium adolescentis DSM20083 prefers beta(1,4)-galactosides over lactose. Appl Microbiol Biotechnol. 2004 Dec;66(3):276-84.