Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEQ4LIN)

DME Name	Carbapenemase (cphA)
Synonyms	Versatile beta-lactamase; Versatile hydrolytic beta-lactamase; Beta-lactamase II; Carbapenem-hydrolyzing metallo-beta-lactamase; Metallo-beta-lactamase type 2b; Metallo-beta-lactamase type IIb
Gene Name	ampC
UniProt ID	Q8L1M8_9ENTR
INTEDE ID	DME2025
EC Number	EC: 3.5.2.6 Hydrolases Carbon-nitrogen hydrolase Cyclic amide hydrolase EC: 3.5.2.6
Lineage	Species: Citrobacter youngae Kingdom: Bacteria Phylum: Proteobacteria Class: Gammaproteobacteria Order: Enterobacterales Family: Enterobacteriaceae Genus: Citrobacter Species: Citrobacter youngae
Tissue Distribution	Primarily distributed in human gut.
Sequence	MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYY FTWGKADIANNRPITQNTLFELGSVSKTFNGVLGGDAIARGEIKLSDPVTRYWPELTGKQ WQNISLLHLATYTAGGLPLQIPNEVTNKTALLRFYQNWQPQWAPGAKRLYANSSIGLFGV LAVKPSGMSYEEAMIRRVLQPLKLTHTWITVPQSEQRDYAWGYRDGKPVHVSPGQLDAEA YGVKSSIMDMARWVQANMDASHVQEKTLQQGIGLAQSRYWRIGEMYQGLGWEMLNWPVKA DTIINGSDSKIALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFIPEKNLGIVMLA NKSYPNPARVDAAWRILEKLQ
Function	This enzyme hydrolyzes beta-lactam.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Imipenem	DMI9FBP	Bacteremia	1A73	Approved	[1]
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References

1	Occurrence of a new metallo-beta-lactamase IMP-4 carried on a conjugative plasmid in Citrobacter youngae from the People's Republic of China. FEMS Microbiol Lett. 2001 Jan 1;194(1):53-7.