Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEQ58KF)

• DME Name: Linoleate isomerase (lai)
• Synonyms: Linoleic acid isomerase; C12 isomerase; LA isomerase; Linoleate DELTA12-cis/DELTA11-trans isomerase; Linoleic acid DELTA12-cis/DELTA11-trans-isomerase; LA-I; LAI; LAI12
• Gene Name: lai
• UniProt ID: D2BQ64_LACLK
• INTEDE ID: DME1179
• EC Number:
  EC: 5.2.1.5
  Isomerase
  Cis-trans-isomerase
  Cis-trans isomerase
  EC: 5.2.1.5
• Lineage:
  Species: Butyrivibrio fibrisolvens
  Kingdom: Bacteria
  Phylum: Firmicutes
  Class: Clostridia
  Order: Clostridiales
  Family: Lachnospiraceae
  Genus: Butyrivibrio
  Species: Butyrivibrio fibrisolvens
  Subspecies: Butyrivibrio fibrisolvens A38
• Tissue Distribution: Primarily distributed in human gut and stomach.
• Sequence:
  MRYTNGNYEAFVHPRKPENVDQKSAYIIGAGLAGLATAVFLIRDGQMSGDRIHILEELPL
  SGGSLDGSFIPHDGFVVRGGREMENHFECLWDLFRTIPSLEVDNASVLDEFYRIDRDDPN
  SSNCRIIHNRGERVDDDGKFTLSPKAQEEIIKLFMTKEELLVGKTIEDCFTDEFFESNFW
  LYWCSMFAFEKWHSAIEMRRYIMRFIHHIEGLPDFSALKFTKYNQYESLVKPLISYLKDH
  GVDFKYGAQVENVEVDFSNGKKVAKAIVFADKKIKELTENDLVFVTNGSITESSTQGSPT
  QAAPKTSELGGSWKLWQNLAKQSEEFGHPDVFCKDIPKETWVVSATVTWENLKIQPYFEK
  LTHRQLRSGKVVTGGIITVKDSNWLLSFTTHRQPHFKEQNDQETVTWVYGLLSNTPGNYI
  KKPIEDCTGEEITQELLYHLGMPEEEIEAFVKENTNTIPVYMPFITSYFMLREPGDRPLV
  VPEQSVNLAFLGNFAETERDTVFTTEYSVRTAMEAVYQLLNVDRGVPEVYASAYDLRTLA
  SSAYYLSDKQKLEDLELSFIKKQALKVGLKKIKGTYIEELLEDAGLI
• Function: This enzyme takes part in linoleic acid metabolism and catalyzes the conversion of 9-cis,12-cis-octadecadienoate to 9-cis,11-trans-octadecadienoate.

Molecular Interaction Atlas (MIA) of This DME

1 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
LINOLEIC ACID	DMDGPY9	Discovery agent	N.A.	Investigative	[1], [2]

References

• [1] Cell-associated alpha-amylases of butyrate-producing Firmicute bacteria from the human colon. Microbiology. 2006 Nov;152(Pt 11):3281-3290.
• [2] Effect of linoleic acid concentration on conjugated linoleic acid production by Butyrivibrio fibrisolvens A38. Appl Environ Microbiol. 2000 Dec;66(12):5226-30.