Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEQ90PB)

DME Name	Dihydroorotase (pyrC)
Synonyms	Carbamoylaspartic dehydrase; Dihydroorotate dehydrolase; Dihydroorotase; BcDHOase; DHOase; DHO; A8806_10260; SAMN05216536_10260; pyrC
Gene Name	pyrC
UniProt ID	A0A2Y9B958_9FIRM
INTEDE ID	DME1829
EC Number	EC: 3.5.2.3 Hydrolases Carbon-nitrogen hydrolase Cyclic amide hydrolase EC: 3.5.2.3
Lineage	Species: Faecalicatena orotica Kingdom: Bacteria Phylum: Firmicutes Class: Clostridia Order: Clostridiales Family: Lachnospiraceae Genus: Faecalicatena Species: Faecalicatena orotica Subspecies: Faecalicatena orotica ATCC 25750
Tissue Distribution	Primarily distributed in human gut.
Sequence	MILIKNGRVIDPKSGMDETIDILIDEGKIVGLGKYKRSNEYEHVIEAEGKIVAPGLIDIH VHFRDPGLTYKEDIESGALAAASGGFTTVVCMANTKPTVDNKETLEYVLEKGRQTGIHVM SVAAVTKGMQGQELTDFRELKEAGAAGLSDDGIPIKDSKLMYEAMAKARDAGMPVSLHEE DPDYVIQAGINKGTVSDELGIGGAMALSEQLMVARDCLLALETGARVNIQHVSSRISVEY IRLAQKLGADVWAEATPQHFSLTEETALEKKTLAKVNPPLRTQEDRYGILEGLKDGTIQI IATDHAPHSTEEKEKPITQAPSGLIGLETSLALGITNLVRTGILTMEYMLKKMTLNPARL YGLDVGYIAKGAPADIVIFDEFEKWKVEKFHSKSCNSPFIGEELYGKVKYTICAGRIVYE DK
Function	This enzyme catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Clinical Trial Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
NSC-14983	DMRAX19	N. A.	N. A.	Phase 1	[1]
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References

1	Enzyme elements involved in the interconversion of L-carbamylaspartate and L-dihydroorotate by dihydroorotase from Clostridium oroticum. Arch Biochem Biophys. 1985 Dec;243(2):447-53.