Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEQB4LT)

DME Name	Beta-galactosidase (bgaB)
Synonyms	Beta-galactosidase/glucuronidase; Beta-galactosidase BgaBeta; Beta-Gal II; Beta-gal; C8D82_10873
Gene Name	bgaB
UniProt ID	A0A2U1B4D0_9BACT
INTEDE ID	DME1139
EC Number	EC: 3.2.1.23 Hydrolases Glycosylase O/S-glycosyl compound glycosidase EC: 3.2.1.23
Lineage	Species: Victivallis vadensis Kingdom: Bacteria Phylum: Lentisphaerae Class: Lentisphaeria Order: Victivallales Family: Victivallaceae Genus: Victivallis Species: Victivallis vadensis Subspecies: Victivallis vadensis ATCC BAA-548
Tissue Distribution	Primarily distributed in human gut.
Sequence	MTVIRNFRRILHGGDYNPDQWLHVPGTVDRDFELMDEAHCNTFSVAIFSWAQLEPEPDRF EFGWLDDIFERCGKSGKKLFLATPSASKPAWLAQRWPDSCRMDRDGTRQRWGVRQNSCFA SPGFRERVRLINRKLAERYADHPALGGWHISNEYHGECACELCRNRFYDYLKQRYGTLEK LNQVYWSAFWGHTFTDWKQVEPFDHSMDAAALDWRRFCSDAVVEFFRMEIDAVREFSDAP VTTNMMGLFPTLDYWKFAPLCDFICDDCYPTWYDGDTEREAAWLSLLHDMHYTMLDKPFV MMESCPGIPNYKPYPKLRRPGEFEREMLLALGHGADGTLYFQWRKGRNNCEKFHGAVVGH DGTDRTMVFRQVAAYGEKLERIAGLADAAKKPEAAVVYDWESNWAFEQCNCAGGKEVKQW DATAISHYRALWNCNIDLAVIDSEQDFSRYKLLVAPMLFMFKPGVLERFRSFVEQGGTLV ATYFSGYVDENNGCFLGGNPGGAAGRELFGVWSEDFDGLQPTTRQSIVWKGKSYPVTDYA ELLHAEGAEVEAVYGDDFYAGTPAVTRKRAGKGNVIYLGARTGMEFLNDFYGALLKESGV EPVLAGLPETVRAARRSAVSGGDYFFLYNLSGKEQPVKLPEAMEDVWNGGGAADTVTLPP NGATVLYRA
Function	This enzyme hydrolyzes alpha-L-arabinoside and beta-D-fucosides and beta-D-glucosides.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Clinical Trial Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lactose	DMO4GPK	Discovery agent	N.A.	Phase 1	[1]
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1 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PNA-D-glucopyranoside	DMPUC8I	N. A.	N. A.	Investigative	[1]
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References

1	Identification and characterization of a novel beta-galactosidase from Victivallis vadensis ATCC BAA-548, an anaerobic fecal bacterium. J Microbiol. 2012 Dec;50(6):1034-40.