Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEQMBHW)

DME Name	Dipeptidase (pepV)
Synonyms	Dipeptidase pepV; Glycosyl-phosphatidylinositol-anchored renal dipeptidase; F4V48_10275; RU90_GL001300; pepV
Gene Name	pepV
UniProt ID	Q84BU9_LACLH
INTEDE ID	DME1002
EC Number	EC: 3.4.13.- Hydrolases Peptidase Dipeptidase EC: 3.4.13.-
Lineage	Species: Lactococcus lactis Kingdom: Bacteria Phylum: Firmicutes Class: Bacilli Order: Lactobacillales Family: Streptococcaceae Genus: Lactococcus Species: Lactococcus lactis Subspecies: Lactococcus lactis subsp. hordniae (hT) Subspecies: Lactococcus lactis subsp. cremoris (L6) Subspecies: Lactococcus lactis subsp. lactis (L9)
Tissue Distribution	Primarily distributed in human gut.
Sequence	MTTIDFKAEVEKLKDALMEDLFSLLRIDSAMDMEHADAENPFGPGPRKALDAFLKIAERD GYTTKNYDNYVGHFEYENGASDDAEVLGIIGHLDVVPAGSGWDSNPFEPEIRNGNLYARG ASDDKGPTVACYYALKILKELNLPLSKKIRFIVGTNEETGWADMDYYFEHCELPLPDFGF SPDAEFPIINGEKGNITEYLHFAGKNAGEVVLHSFKAGLAENMVPESATAVISGAKDLQA ALEKFVAEHASKNLRFDLEETAGKATVTLYGKSAHGAMPEKGVNGATYLTLFLNQFNFAD GAAAFIKVGAEKLLEDHEGEKLGTAYVDELMGNTSMNAGVWSFDENSEGKIALNFRFPQG NSPERMQEILAKLDGVVEVELSKHLHVPHYVPMSDPLVSTLIDVYEKHTGLKGYETIIGG GTFGRLLERGVAYGAMFEGEPDSMHQANEMKPVENIYKAAVIYAEAIYELTK
Function	This enzyme catalyzes the conversion of dipeptides into amino acids.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

3 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Enalapril	DMNFUZR	Congestive heart failure	BD10	Approved	[1]
Enalaprilat	DMFYAM1	Congestive heart failure	BD10	Approved	[1]
Spirapril	DM5XLTY	Hypertension	BA00-BA04	Approved	[1]
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References

1	Characterization and kinetic analysis of enzyme-substrate recognition by three recombinant lactococcal PepVs. Arch Biochem Biophys. 2006 Oct 15;454(2):137-45.