Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEQOJDP)

DME Name	Cytochrome P450 111A2 (cyp111)
Synonyms	Cytochrome P450 family 111 subfamily A member 2; Flavocytochrome P450 111A2; P450 111A2; cyp111A2
Gene Name	cyp111
UniProt ID	A0A2S6X9I3_9ACTN
INTEDE ID	DME1567
EC Number	EC: 1.14.14.1 Oxidoreductase Oxygen paired donor oxidoreductase Flavin/flavoprotein donor oxidoreductase EC: 1.14.14.1
Lineage	Species: Novosphingobium aromaticivorans Kingdom: Bacteria Phylum: Proteobacteria Class: Alphaproteobacteria Order: Sphingomonadales Family: Sphingomonadaceae Genus: Novosphingobium Species: Novosphingobium aromaticivorans Subspecies: Novosphingobium aromaticivorans DSM 12444
Tissue Distribution	Primarily distributed in human gut.
Sequence	MSEETISQTVPPVREWPAIDLPGSDFDPVLTELMREGPVTRISLPNGEGWAWLVTRHDDV RLVTNDPRFGREAVMDRQVTRLAPHFIPARGAVGFLDPPDHTRLRRSVAAAFTARGVERV RERSRGMLDELVDAMLRAGPPADLTEALLSPFPIAVICELMGVPATDRHAMHTWTQLILS SSHGAEVSERAKNEMNAYFSDLIGLRSDSTGEDVTSLLGAAVGRGEITLTEAVGLAVLLQ IGGEAVTNNSGQMFHLLLSRPELAERLRSDPALRPRAIDELLRWIPHRNAVGLSRIALED VEVKGARIRAGDAVYVSYLAANRDPEVFPDPDTIDFDRSPNPHVSFGFGPHYCPGGMLAR LESELLVDAVLDRVPGLKLAVAPEDVPFKKGALIRGPEALPVTW
Function	This enzyme is a cytochrome P-450 (heme-thiolate) protein.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
linalool	DMGZQ5P	Discovery agent	N.A.	Investigative	[1], [2]
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References

1	Patients with primary biliary cirrhosis react against a ubiquitous xenobiotic-metabolizing bacterium. Hepatology. 2003 Nov;38(5):1250-7.
2	A cytochrome P450 class I electron transfer system from Novosphingobium aromaticivorans. Appl Microbiol Biotechnol. 2010 Mar;86(1):163-75.