Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEQUGC0)

DME Name	D-Lactate dehydrogenase (ldhA)
Synonyms	Glycolate dehydrogenase; D-lactate ferricytochrome C oxidoreductase; Fermentative lactate dehydrogenase; D-LDH; Q058_03541; ldhA
Gene Name	ldhA
UniProt ID	A0A1C7BXR3_PSEAI
INTEDE ID	DME1116
EC Number	EC: 1.1.1.28 Oxidoreductase CH-OH donor oxidoreductase NAD/NADP oxidoreductase EC: 1.1.1.28
Lineage	Species: Megasphaera elsdenii Kingdom: Bacteria Phylum: Firmicutes Class: Negativicutes Order: Veillonellales Family: Veillonellaceae Genus: Megasphaera Species: Megasphaera elsdenii
Tissue Distribution	Primarily distributed in human gut.
Sequence	MRILFFSSQAYDSESFQASNHRHGFELHFQQAHLQADTAVLAQGFEVVCAFVNDDLSRPV LERLAAGGTRLVALRSAGYNHVDLAAAEALGLPVVHVPAYSPHAVAEHAVGLILTLNRRL HRAYNRTREGDFSLHGLTGFDLHGKRVGVIGTGQIGETFARIMTGFGCELLAYDPYPNPR IQALGGRYLALDALLAESDIVSLHCPLTADTRHLIDAQRLATMKPGAMLINTGRGALVNA AALIEALKSGQLGYLGLDVYEEEADIFFEDRSDQPLQDDVLARLLSFPNVVVTAHQAFLT REALAAIADTTLDNIAAWQDGTPRNRVRA
Function	This enzyme has D-lactate dehydrogenase activity.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
D-glucose	DMMG2TO	Discovery agent	N.A.	Investigative	[1], [2]
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References

1	Presence of lactate dehydrogenase and lactate racemase in Megasphaera elsdenii grown on glucose or lactate. Appl Environ Microbiol. 1993 Jan;59(1):255-9.
2	hole-Genome sequence of a Megasphaera elsdenii strain isolated from the gut of a healthy Indian adult subject. Genome Announc. 2017 Oct 19;5(42):e01033-17.