Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DES378D)

DME Name	Methylthioribose kinase (mtnK)
Synonyms	MTR kinase; 5-deoxyribose disposal kinase; 5-deoxyribose kinase; mtnK; mtrK
Gene Name	mtnK
UniProt ID	MTNK_KLEPN
INTEDE ID	DME1916
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
EC Number	EC: 2.7.1.100 Transferase Kinase Phosphotransferase EC: 2.7.1.100
Lineage	Species: Klebsiella pneumoniae Kingdom: Bacteria Phylum: Proteobacteria Class: Gammaproteobacteria Order: Enterobacterales Family: Enterobacteriaceae Genus: Klebsiella Species: Klebsiella pneumoniae
Tissue Distribution	Primarily distributed in human gut.
Sequence	MSQYHTFTAHDAVAYAQQFAGIDNPSELVSAQEVGDGNLNLVFKVFDRQGVSRAIVKQAL PYVRCVGESWPLTLDRARLEAQTLVAHYQHSPQHTVKIHHFDPELAVMVMEDLSDHRIWR GELIANVYYPQAARQLGDYLAQVLFHTSDFYLHPHEKKAQVAQFINPAMCEITEDLFFND PYQIHERNNYPAELEADVAALRDDAQLKLAVAALKHRFFAHAEALLHGDIHSGSIFVAEG SLKAIDAEFGYFGPIGFDIGTAIGNLLLNYCGLPGQLGIRDAAAAREQRLNDIHQLWTTF AERFQALAAEKTRDAALAYPGYASAFLKKVWADAVGFCGSELIRRSVGLSHVADIDTIQD DAMRHECLRHAITLGRALIVLAERIDSVDELLARVRQYS
Function	This enzyme catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylthioribose phosphate	DMU3JBL	N. A.	N. A.	Investigative	[1]
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References

1	Selective killing of Klebsiella pneumoniae by 5-trifluoromethylthioribose. Chemotherapeutic exploitation of the enzyme 5-methylthioribose kinase. J Biol Chem. 1990 Jan 15;265(2):831-7.