Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DESGYWE)

• DME Name: Aminoglycoside O-phosphotransferase (aphA6)
• Synonyms: Aminoglycoside 3'-phosphotransferase; Kanamycin kinase, type VI; Neomycin-kanamycin phosphotransferase type VI; APH(3')VI; AphA6; aphA-6; aphA6
• Gene Name: aphA6
• UniProt ID: G9FRK8_PROST
• INTEDE ID: DME1142
• EC Number:
  EC: 2.7.1.95
  Transferase
  Kinase
  Phosphotransferase
  EC: 2.7.1.95
• Lineage:
  Species: Providencia stuartii
  Kingdom: Bacteria
  Phylum: Proteobacteria
  Class: Gammaproteobacteria
  Order: Enterobacterales
  Family: Morganellaceae
  Genus: Providencia
  Species: Providencia stuartii
• Tissue Distribution: Primarily distributed in human gut.
• Sequence:
  GNSVLEPNKIGQSPSDVYSFNRNNETFFLKRSSTLYTETTYSVSREAKMLSWLSDKLKVP
  ELIMTFQDEQFEFMITKAINAKPISALFLTEQELLAIYKETLNQLNAVAIIDCPFISSID
  HRLKESKFFIDNQLLDEIDQDDLDAELWGDHKTYISLWNELNETRVEERLVFSHGDITDS
  NIFIDKSGEIYFLDLGRAGLADEFVDISFVERCLREDVSEETAKIFLKHLKNDRPDKR
• Function: This enzyme acts on the antibiotics neomycin, paromomycin, neamine, paromamine, vistamycin and gentamicin A.

Molecular Interaction Atlas (MIA) of This DME

1 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Plazomicin	DMKMBES	Bronchitis	CA20	Approved	[1]

References

• [1] Plazomicin retains antibiotic activity against most aminoglycoside modifying enzymes. ACS Infect Dis. 2018 Jun 8;4(6):980-987.