Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DESR17C)

DME Name L-Lactate dehydrogenase (ldh)
Synonyms L-lactate ferricytochrome C oxidoreductase; Cytochrome b2 mitochondrial; L-LCR; L-LDH; ldh
Gene Name ldh
UniProt ID
LDH_LACCA
INTEDE ID
DME1512
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Gene ID
31583240
EC Number EC: 1.1.1.27
Oxidoreductase
CH-OH donor oxidoreductase
NAD/NADP oxidoreductase
EC: 1.1.1.27
Lineage Species: Lactobacillus casei
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Lactobacillaceae
Genus: Lactobacillus
Species: Lactobacillus casei

Subspecies: Lactobacillus casei ATCC 393
Tissue Distribution Primarily distributed in human gut.
Sequence
MASITDKDHQKVILVGDGAVGSSYAYAMVLQGIAQEIGIVDIFKDKTKGDAIDLSNALPF
TSPKKIYSAEYSDAKDADLVVITAGAPQKPGETRLDLVNKNLKILKSIVDPIVDSGFNGI
FLVAANPVDILTYATWKLSGFPKNRVVGSGTSLDTARFRQSIAEMVNVDARSVHAYIMGE
HGDTEFPVWSHANIGGVTIAEWVKAHPEIKEDKLVKMFEDVRDAAYEIIKLKGATFYGIA
TALARISKAILNDENAVLPLSVYMDGQYGLNDIYIGTPAVINRNGIQNILEIPLTDHEEE
SMQKSASQLKKVLTDAFAKNDIETRQ
Function This enzyme catalyzes the conversion of lactate to pyruvate, and it also oxidizes other (S)-2-hydroxymonocarboxylic acids.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DME
1 Clinical Trial Drug(s) Metabolized by This DME
Drug Name Drug ID Indication ICD 11 Highest Status REF
DB-053072 DM1K248 N. A. N. A. Phase 1 [1]
1 Investigative Drug(s) Metabolized by This DME
Drug Name Drug ID Indication ICD 11 Highest Status REF
Glucose-bisphosphate DMMJQ7O N. A. N. A. Investigative [1]

References

1 Purification, properties and immunological relationship of L (+)-lactate dehydrogenase from Lactobacillus casei. Eur J Biochem. 1976 Aug 16;67(2):543-55.