Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEST6E5)

• DME Name: Alpha-glucosidase (aglA)
• Synonyms: Oligo-1,6-glucosidase; 6-phospho-alpha-glucosidase 1; DW040_17105; ERS852394_00764; malL_1
• Gene Name: malL_1
• UniProt ID: A0A173ZA10_9FIRM
• INTEDE ID: DME1138
• Gene ID: 42449350
• EC Number:
  EC: 3.2.1.20
  Hydrolases
  Glycosylase
  O/S-glycosyl compound glycosidase
  EC: 3.2.1.20
• Lineage:
  Species: Blautia obeum
  Kingdom: Bacteria
  Phylum: Firmicutes
  Class: Clostridia
  Order: Clostridiales
  Family: Lachnospiraceae
  Genus: Blautia
  Species: Blautia obeum
• Tissue Distribution: Primarily distributed in human gut.
• Sequence:
  MEKKWWKESVVYQIYPKSFKDSNGDGVGDIRGIIQKLDYLKELGVNVLWISPMLESPQDD
  NGYDISDYRRIYKEYGTMEDYEELLSEAHKRDIRILMDLVVNHTSDEHNWFIESRKSKDN
  PYRDYYIWKDPVNGKEPNNWGGVFGGSAWEYDAQTQMYYLHLFSKKQPDLNWENEKVRQE
  VYDMMTFWCEKGIDGFRMDVISMISKDQAFPDGKMNNSLYGDFGPYCVHGPRIHEFLQEM
  NREVLSRYDIMTVGETSGVTIEEAQKYAGEAGKELNMVFQFEHVDNGSGDYGKWTTEKYD
  FKEFKRIMIKWQEELQGKAWNSLFLGNHDQPRSVSRFGNDNPAYRETSAKMLATCLHMMQ
  GTPYVYQGEELGMTNVYFDKLEDYRDIESINFFTELTESGLMTPEYMMKCLMLRSRDNAR
  TPMQWDDSEQAGFTDGESWIKVNPNYKEINAAQQLKDPNSIFHYYQKLISLRKEKDIIVY
  GEFEPLYRDDEQIFAYTRKLDQEKLLTVCNFSDKNAEMEIPEEFKGAECLITNLDRTVFE
  GKIVLKPYEAFVLYKK
• Function: This enzyme is probably involved in the catabolism of alpha-glycosides accumulated via a phosphoenolpyruvate-dependent phosphotransferase system (PEP-PTS). And it hydrolyzes a wide variety of 6-phospho-alpha-D-glucosides including the five isomeric derivatives of sucrose, i.e. trehalulose-6'-phosphate, turanose-6'-phosphate, maltulose-6'-phosphate, leucrose-6'-phosphate, and palatinose-6'-phosphate, but is not active on sucrose-6-phosphate. Moreover, it can also hydrolyze maltose-6'-phosphate and methyl-alpha-glucose-6-phosphate, and poorly, trehalose-6-phosphate. However, it fails to hydrolyze beta-O-linked phosphorylated disaccharides such as cellobiose-6'-phosphate and gentiobiose-6'-phosphate.

Molecular Interaction Atlas (MIA) of This DME

1 Clinical Trial Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Maltose	DMH0ROP	N. A.	N. A.	Phase 1/2	[1]

1 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isomaltose	DMD1KSW	N. A.	N. A.	Investigative	[1]

References

• [1] Novel alpha-glucosidase from human gut microbiome: substrate specificities and their switch. FASEB J. 2010 Oct;24(10):3939-49.