Details of Drug-Metabolizing Enzyme (DME)
General Information of Drug-Metabolizing Enzyme (DME) (ID: DETD1FG)
| DME Name | Oligosaccharyltransferase (pglB) | ||||
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| Synonyms | Oligosaccharyl transferase pglB; Oligo-saccharyl transferase; pglB; pglB1 | ||||
| Gene Name | pglB1 | ||||
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| EC Number | EC: 2.4.99.19 | ||||
| Lineage | Species: Helicobacter pullorum | ||||
| Tissue Distribution | Primarily distributed in human gut. | ||||
| Sequence |
MQNKNWLLIAVFVYLIAILLRFYYPFVLGEFEEYFYHNALLLNTNDGYFYAQGARDILAG
VKSTFYSPTHEILSQISAFLALILPFSLEQIIFYMPGFFGSLIVFFVVFVSRDFGGIPSF LCGILSAISVSYYNRTMFGYYDTDMLVIVLAFGVGVVIVELMRKISFFGLVLLILLSGFG LVYYPSMRYIFVGYVGILTIFGIFDRNIRMVNGCLLSVLLGFLLFSTHFVFWLFLCFCGV MIKFIQRLDRRIFDFVYCLLLVIFCGILAFRVVPEIFASVYVAQDSKEIVGFGYASVMGT ISEVSKIDFWNFVYRISGNLLWFVLGSVGIILLFLKKREFWIFLPFLIMGFFGYFGGLRF TFYAVVVYALGIGYLLCFLLDIFKRKIKWAVIFGVVFVCGSVFPHLWHIKNYIIPPILEN SEAKALQEIPAKYGDYALAWWDYGYFVRYFARLNTFVDGGIHSGKQNYPISFVLSAKNQK QSYNMAKLTFNHIEFEDFAKSHQYSQSKALEALKGDIDCVGKRSEDLYIILPLRMVRIFS TIMQFSQPKGEINQGLLMVSKTKSKDKIIFQDNVFVDIKKGKVGILNQEISLNIAKMIDL KDSSKSLEFDKNSSLVVLMLGGGDYILCDKEYLETFYFRGMFLDNLDSNLFEKVLKNEKI AIYKLKQ |
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| Function |
This enzyme requires Mn2+ or Mg2+ and forms a glycoprotein by the transfer of a glucosyl-N-acetylgalactosaminyl-N,N'-diacetylbacillosamine (GalNAc2(Glc)GalNAc3diNAcBac) polysaccharide and related oligosaccharides to the side-chain of an L-asparagine residue in the sequence -Asp/Glu-Xaa-Asn-Xaa'-Ser/Thr- (Xaa and Xaa' not Pro) in nascent polypeptide chains.
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Molecular Interaction Atlas (MIA) of This DME
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1 Investigative Drug(s) Metabolized by This DME
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