Details of Drug-Metabolizing Enzyme (DME)
General Information of Drug-Metabolizing Enzyme (DME) (ID: DETP059)
| DME Name | Azoreductase (azoR) | ||||
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| Synonyms | Azo-dye reductase; FMN-dependent NADH-azo compound oxidoreductase; FMN-dependent NADH-azoreductase; azoR; SDY_1775 | ||||
| Gene Name | azoR | ||||
| UniProt ID | |||||
| INTEDE ID | |||||
| 3D Structure | |||||
| Gene ID | |||||
| EC Number | EC: 1.7.1.6 | ||||
| Lineage | Species: Shigella dysenteriae | ||||
| Tissue Distribution | Primarily distributed in human gut. | ||||
| Sequence |
MSKVLVLKSSILAGYSQSNQLSDYLVEQWREKHSADEITVRDLAANPIPVLDGELVGALR
PSDAPLTPRQQEALALSDELIAELKAHDVIVIAAPMYNFNISTQLKNYFDLVARAGVTFR YTENGPEGLVTGKKAIVITSRGGIHKDGPTDLVTPYLSTFLGFIGITDVKFVFAEGIAYG PEMAAKAQSDAKAAIDSIVAA |
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| Function | This enzyme catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. And it requires NADH, but not NADPH, as an electron donor for its activity. | ||||
Molecular Interaction Atlas (MIA) of This DME
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1 Clinical Trial Drug(s) Metabolized by This DME
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